Drugs Books
Related Subjects: Psychedelics Dissociatives
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Used price: $10.95

Survival on the Mean Streets of Calgary and VancouverReview Date: 2005-01-10
On Women's Survival on the Mean StreetsReview Date: 2005-01-10
Snow Bodies-Elizabeth Hudson attended Mount Royal College where she was awarded the Lorraine Hill Award and the George Kirby Scholarship. Her poems have been published in Tower Poetry, Other Voices, Pottersfield Portfolio and Amethyst Review. She has also written articles published in Macleans. Hudson's two sons have both graduated from university, and now she lives in the deep suburbs of Calgary with her husband, three dogs and a cat.

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the realnessReview Date: 2002-06-26
Soft Money, Hard DrugsReview Date: 2001-11-10
The book paints a true to life picture of the dilemma faced by all societies of the world in finding a solution to the destruction rooted in drugs.
The subject of alternate avenues to the unsuccessful "War on Drugs" is one that has not been given due debate by this nation's media.

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Been ThereReview Date: 2004-02-19
From the moment I began reading I slipped back into the past-I laughed, I cried, but most of all, I thanked God for helping me through some pretty hard times, and for people like Gene Mason who have shared their experiences.
Recovery through the eyes of participantsReview Date: 2004-02-12

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A Winning Play by PlayReview Date: 2008-04-13
Dieden artfully weaves his his own painful tale of addiction and eventual recovery along with the memorable quotes from coaches and athletes and their amazing stores of spirit, courage and victory over seemingly impossible odds and facing defeats. Dieden offers a simple plan, practical and spiritual strategies for living life a game at a time. It inspires me to get off the bench and stay in the game. This is an honest, humorous, heartwarming, hopeful book. A sports book for all seasons. A wonderful gift to be read, given, shared
A crucial read for difficult challengesReview Date: 2008-03-20

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An intriguing history.Review Date: 2000-08-04
"Must" reading for students of religion & drug use.Review Date: 2000-09-05

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beautiful expository writing on key issues in drug development and clinical trialsReview Date: 2008-02-07
The introduction gives you a feeling for the approach in the book and how it splits into two parts. Part I, consisting of chapters 2-5, provides some history of the development of statistical methods and some introductory topics that are fundamental to the discussion in Part II.
Part II is the heart of the book where the practical statistical issues in clinical trials are raised. The text is intended for non-statisticians who work in the pharmaceutical industry but to quote part of Senn's preface he states "Although addressed to the life-scientist it is my hope that many statisticians, in particular those studying medical statistics or embarking on a career in drug development, will also find it useful. Above all I hope that it will help communication between the disciplines: a process by which the statistician stands to benefit as much as any other professional in drug development."
I can really appreciate what Senn has done. He explains the issues of intention-to-treat, washout, multiplicity and other problems that I have had to wrestle with and try to explain to MDs and clinical managers. But even more importantly to me than helping me communicate the many issues that I was aware of, he also raises many subtle issues that I was not aware of. This includes questions of bioequivalence, the use of baseline information and particularly percentage change from baseline versus covariate adjustment, problems of inference regarding measurements taken after titration and issuesw in N of 1 trials. I even learned a few new techniques (e.g. Taves minimiization and Atkinson's generalization of it for allocating patients to treatment groups).
The only complaint I can see is that there is not enough detail. However, remember the text was not designed for statisticians and so much of the mathematics and technicalities are deliberately left out.
But Senn does provides a detailed list of relevant references at the end of each chapter that allows the reader to find in texts and journal articles all the detail one might need. Also to aid with communication there is a large glossary of terms at teh back of the book.
This is a great reference for scientists and statisticians as well!
heavy on issues, provocative and with minimal mathematicsReview Date: 2001-10-18
The introduction gives you a feeling for the approach in the book and how it splits into two parts. Part I, consisting of chapters 2-5, provides some history of the development of statistical methods and some introductory topics that are fundamental to the discussion in Part II.
Part II is the heart of the book where the practical statistical issues in clinical trials are raised. The text is intended for non-statisticians who work in the pharmaceutical industry but to quote part of Senn's preface he states "Although addressed to the life-scientist it is my hope that many statisticians, in particular those studying medical statistics or embarking on a career in drug development, will also find it useful. Above all I hope that it will help communication between the disciplines: a process by which the statistician stands to benefit as much as any other professional in drug development."
I can really appreciate what Senn has done. He explains the issues of intention-to-treat, washout, multiplicity and other problems that I have had to wrestle with and try to explain to MDs and clinical managers. But even more importantly to me than helping me communicate the many issues that I was aware of, he also raises many subtle issues that I was not aware of. This includes questions of bioequivalence, the use of baseline information and particularly percentage change from baseline versus covariate adjustment, problems of inference regarding measurements taken after titration and issuesw in N of 1 trials. I even learned a few new techniques (e.g. Taves minimiization and Atkinson's generalization of it for allocating patients to treatment groups).
The only complaint I can see is that there is not enough detail. However, remember the text was not designed for statisticians and so much of the mathematics and technicalities are deliberately left out.
But Senn does provides a detailed list of relevant references at the end of each chapter that allows the reader to find in texts and journal articles all the detail one might need. Also to aid with communication there is a large glossary of terms at teh back of the book.
This is a great reference for scientists and statisticians as well!


great reference, a must have for pharamceutical statisticiansReview Date: 2008-01-22
The book is good for biostatisticians and regulatory affairs specialists as a reference source. All the key statistical issues are addressed and the reader is given the perspective of the ICH and FDA guidance documents. The underlying statistical methodology that justifies the recommendations in the guidances is presented. This is a state-of-the-art book. Shao and Pigeot produced some of the recent research in individual bioequivalence that established a bootstrap procedure as an appropriate way to construct confidence intervals for the problem. Their method is recommended in an FDA guidance document.
But more than just this one example, all the key issues that have been the subject of FDA workshops over the past several years are addressed in this book. These topics include calibration, assay and assay validation, dissolution testing, stability analysis, shelf life estimation, bioequivalence, randomization and blinding, what constitutes substantive evidence in clinical development, therapeutic equivalence and noninferiority, Bayesian approaches in clinical trials, problems involving missing and incomplete data, longitudinal methods, meta-analysis, quality of life studies and instrument validation, and medical imaging.
Other prevalent issues in clinical trials include group sequential methods, hierarchical Bayesian models and multiple testing. These issues are not covered as much in this text as the others we have mentioned. But there is some discussion of multiplicity in the context of quality of life studies. An example of sequential testing is used to illustrate model selection in Chapter 2. The important issues of design and sample size requirements are presented throughout the book.
While not all topics are covered in sufficient depth, the book is remarkable in the breadth of material covered in just 350 pages of text. The authors also provide a very authoritative list of references and regulatory guidances and other documents.
belongs on desk of every pharmaceutical biostatisticianReview Date: 2002-09-10
The book is good for biostatisticians and regulatory affairs specialists as a reference source. All the key statistical issues are addressed and the reader is given the perspective of the ICH and FDA guidance documents. The underlying statistical methodology that justifies the recommendations in the guidances is presented. This is a state-of-the-art book. Shao and Pigeot produced some of the recent research in individual bioequivalence that established a bootstrap procedure as an appropriate way to construct confidence intervals for the problem. Their method is recommended in an FDA guidance document.
But more than just this one example, all the key issues that have been the subject of FDA workshops over the past several years are addressed in this book. These topics include calibration, assay and assay validation, dissolution testing, stability analysis, shelf life estimation, bioequivalence, randomization and blinding, what constitutes substantive evidence in clinical development, therapeutic equivalence and noninferiority, Bayesian approaches in clinical trials, problems involving missing and incomplete data, longitudinal methods, meta-analysis, quality of life studies and instrument validation, and medical imaging.
Other prevalent issues in clinical trials include group sequential methods, hierarchical Bayesian models and multiple testing. These issues are not covered as much in this text as the others we have mentioned. But there is some discussion of multiplicity in the context of quality of life studies. An example of sequential testing is used to illustrate model selection in Chapter 2. The important issues of design and sample size requirements are presented throughout the book.
While not all topics are covered in sufficient depth, the book is remarkable in the breadth of material covered in just 350 pages of text. The authors also provide a very authoritative list of references and regulatory guidances and other documents.

Used price: $4.69

So Many Ways to Stay SoberReview Date: 2008-01-17
Michael Z, Author The Wisdom of the Rooms A Year of Weekly Reflections
HelpfulReview Date: 2006-07-08

Used price: $11.27

Important but little known historyReview Date: 2004-07-28
Critical historical context for the War on DrugsReview Date: 2007-03-19
This book provides the historical framework critical to understand this, with the War on Drugs beginning as an attempt to provide what equates to trade protection to the pharmaceutical companies (who competed with the real thing of the day, opium/heroin), and how later racism led to marijuana users being targeted as well (Black Americans in Harlem and Latinos in the SW and California), and of course the violence fueled by the cocaine/crack trade made it a national buzzword.
It is a crime that this assault on our own citizens continues today - one would think that after the dismal failure of Prohibition that we would have learned our lesson.
Hopefully this book can start raising a consciousness to question it, at the very least more public debate (without the hysteria) is long overdue.

Used price: $18.34

Great Buy....Fast ShippingReview Date: 2006-08-16
Thank you.
Great transactionReview Date: 2006-03-16
Related Subjects: Psychedelics Dissociatives
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Snow Bodies-Elizabeth Hudson attended Mount Royal College where she was awarded the Lorraine Hill Award and the George Kirby Scholarship. Her poems have been published in Tower Poetry, Other Voices, Pottersfield Portfolio and Amethyst Review. She has also written articles published in Macleans. Hudson's two sons have both graduated from university, and now she lives in the deep suburbs of Calgary with her husband, three dogs and a cat.