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Related Subjects: Nabhan, Gary Paul Nash, Ogden Nashe, Thomas Nelson, Marilyn Neruda, Pablo Nye, Naomi Shihab Nabokov, Vladimir Nin, Anais Neri, Kris Nicholson, Peter Nesbit, Edith Ngugi wa Thiong'o Norris, Robert W. Nicholson, Geoff Novalis Novo, Salvador Nooteboom, Cees Newman, Amy Niland, D'Arcy Narayan, R. K. Nassise, Joseph Nichol, B. P. Nasaw, Jonathan Nottingham, Theodore J.
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Related Subjects: Nabhan, Gary Paul Nash, Ogden Nashe, Thomas Nelson, Marilyn Neruda, Pablo Nye, Naomi Shihab Nabokov, Vladimir Nin, Anais Neri, Kris Nicholson, Peter Nesbit, Edith Ngugi wa Thiong'o Norris, Robert W. Nicholson, Geoff Novalis Novo, Salvador Nooteboom, Cees Newman, Amy Niland, D'Arcy Narayan, R. K. Nassise, Joseph Nichol, B. P. Nasaw, Jonathan Nottingham, Theodore J.
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Breaking Out : A Woman's Guide to Coping with Acne at Any Age
Published in Paperback by (2004-06-29)
List price: $13.00
New price: $9.16
Used price: $8.26
Used price: $8.26
Average review score: 

Great Starting Point to Understanding Acne
Helpful Votes: 0 out of 1 total.
Review Date: 2008-02-08
Review Date: 2008-02-08
I LOVED this book. Lydia uses tons of references and provides the reader with varying opinions on acne. She readily admits that there isn't one universal cure for acne and her research is extensive. I recommend this book to all of my clients who suffer from acne. There is a comprehensive bibliography as well where you can find books with more in-depth information.
A quick resource
Helpful Votes: 0 out of 1 total.
Review Date: 2007-12-19
Review Date: 2007-12-19
I enjoyed this book, but I think pictures would be useful to clarify the text.
Good Introduction
Helpful Votes: 2 out of 2 total.
Review Date: 2008-03-27
Review Date: 2008-03-27
After finding myself trying several OTC programs which didn't work, I stumbled across this book. I had no idea that I had been using BP all wrong! FYI, BP is not a spot treatment for pimples with white showing. I also had no idea that salicylic acid products had to be of a pH between 3 and 4 to be most effective. I wish the author would have tested more salicylic acid products for the appropriate pH. Only a couple of the ones she tested had the requisite pH. I would have much rather had a large list of products with the recommended pH than a large list of products without it. Also, I agree with a previous reviewer that pictures would be most helpful, especially in describing the formation of acne and what the different kinds of acne look like. Overall, I found that this book is a good introduction to the world of acne, but definitely not a place to stop learning.
I thought I knew something about acne...
Helpful Votes: 2 out of 2 total.
Review Date: 2008-01-03
Review Date: 2008-01-03
Do you believe that if a product dries out your face, your skin will overcompensate by producing more oil? Do you think a special scrub can unplug your pores and help free you from blackheads? Or maybe you cherish the belief that you can sweat your pores clean of acne-causing dirt or toxins through vigorous exercise or steam treatments? If so, you need to read this book.
I have never realized how poorly I understood acne, and I am amazed how many myths I let myself absorb from "informative" commercials and advice given by well-intentioned editors of numerous women's magazines. I am immensely grateful to the author for teaching me what acne is - really and exactly - and for doing so in an accessible and friendly manner. Just the chapter "Understanding Acne" alone is worth the money I spent on this book, because it's hard to fight the condition without understanding it, and because it simply feels good to know for once what is going on with my skin.
I have never realized how poorly I understood acne, and I am amazed how many myths I let myself absorb from "informative" commercials and advice given by well-intentioned editors of numerous women's magazines. I am immensely grateful to the author for teaching me what acne is - really and exactly - and for doing so in an accessible and friendly manner. Just the chapter "Understanding Acne" alone is worth the money I spent on this book, because it's hard to fight the condition without understanding it, and because it simply feels good to know for once what is going on with my skin.
Unbelievably helful in controlling adult acne
Helpful Votes: 2 out of 2 total.
Review Date: 2007-12-11
Review Date: 2007-12-11
I have had cystic acne since I was a teen. I'm now 42 and there are no signs of it going away. I see a dermatologist regularly. I have tried literally hundreds of skincare products.
I purchased this book, read it cover to cover, and changed my skincare routine in response. I am using products I already had - a mix of OTC and prescription items - I just didn't have a good plan for using them.
To my amazement, I have now gone six weeks without a cyst. This may be the longest cyst-free period in my adult life.
Lydia Preston, you are my hero.
UPDATE: Three months, no cysts. I could seriously cry!
I purchased this book, read it cover to cover, and changed my skincare routine in response. I am using products I already had - a mix of OTC and prescription items - I just didn't have a good plan for using them.
To my amazement, I have now gone six weeks without a cyst. This may be the longest cyst-free period in my adult life.
Lydia Preston, you are my hero.
UPDATE: Three months, no cysts. I could seriously cry!

The Breast Cancer Survival Manual: A Step-By-Step Guide for the Woman With Newly Diagnosed Cancer
Published in Paperback by (2000-03-31)
List price: $15.00
New price: $5.90
Used price: $5.63
Used price: $5.63
Average review score: 

An absolute must-have for anyone diagnosed with b.c.
Helpful Votes: 0 out of 0 total.
Review Date: 2008-03-06
Review Date: 2008-03-06
When I was diagnosed in 2005, I was absolutely overwhelmed with fear, information, and decisions. This book is the only one I found that made sense to me. It is clear, concise, and very encouraging. Dr. Link's approach is from a place of genuine respect and regard, and he knows exactly what survivors need to know right away. Reading this book really helped me make the best treatment decisions for myself, with the best information available. The book teaches survivors (who for the most part are not medical professionals, but will unfortunately have to get to that level pretty quickly) how to read pathology reports, and helps you formulate the questions you need to have answered to make your choices. I recommend it to everyone I know who is newly diagnosed.
Breast Cancer Survival Guide
Helpful Votes: 0 out of 0 total.
Review Date: 2008-02-18
Review Date: 2008-02-18
Very good basic guide for one suffering from breast cancer, one problem was that it was 8 years outdated. Would have been better had it been updated, new treatments are always being discovered. It was a good overview, though.
The Breast Cancer Survival Manual
Helpful Votes: 0 out of 0 total.
Review Date: 2007-12-18
Review Date: 2007-12-18
A book for those who are newly diagnosed with cancer. The book describes in detail the different stages of breast cancer. It also discusses how individuals should see doctors for a second opinion. Another great part about the book is the differences in opinion about how to manage breast cancer, and the different paths to take.
Usefull general info
Helpful Votes: 0 out of 0 total.
Review Date: 2007-10-26
Review Date: 2007-10-26
I bought this book when my mother was diagnosed with breast cancer. The first advice it gives was a breath of fresh air in the middle of a maelstrom. It simply said "you have time." It also gives great advice on second opinions. Besides this first advice the book is filled with general information written in easy to understand english. Some of the info applies some of it doesn't, everyones cancer is different. I greatly recomend this book to all those of us faced with this challenge. It provides you with the information doctors usually don't take the time to give you. A must read before your next doctors visit. One caveat: if you are looking for a feel good read this is not it... this is a serious book of medical information.
The Breast Cancer Survival Manual
Helpful Votes: 0 out of 0 total.
Review Date: 2007-10-04
Review Date: 2007-10-04
I just had this mailed to a friend who was recently diagnosed with very aggressive Breast Cancer. She is only 41. When I was 41 in 2000, I was also diagnosed. This book helped me so much! It is informative and easy to understand. It is not a dry read, like other books on this subject. Most importantly, it is not a downer. While this book is realistic it is also upbeat. I tried reading Dr. Susan Love's book and it was so depressing I could only read one chapter.

Children Just Like Me
Published in Hardcover by (1995-10-01)
List price: $19.95
New price: $14.10
Used price: $6.56
Used price: $6.56
Average review score: 

Very interesting
Helpful Votes: 0 out of 0 total.
Review Date: 2007-06-29
Review Date: 2007-06-29
My 6 year old loves reading this book. It shows how children around the world dress, live, and play. It is interesting to see what other children like to do for fun, or what they like to eat. It is also teaching her about the different countries around the world.
My daughter's favorite book
Helpful Votes: 1 out of 1 total.
Review Date: 2007-08-03
Review Date: 2007-08-03
This awesome book shows children around the world and what their everyday life is like (homes, schools, families, pets, friends, churches, food). Having a daughter adopted internationally,this book helps us learn more about her birth country and about all the children of the world. We've started giving this as birthday gifts to her friends.
Expanding Awareness
Helpful Votes: 1 out of 1 total.
Review Date: 2007-02-21
Review Date: 2007-02-21
I hope that all children can someday enjoy this book with their friends and caring adults. It makes real the lives of children all around the world - their hopes, their dreams, their families and their daily routines. It's a delight to see our similarities and a great lesson to learn about our differences. Thank you to the authors and publishers.
A great way to introduce your children to the wider world
Helpful Votes: 1 out of 1 total.
Review Date: 2007-01-16
Review Date: 2007-01-16
My family and I love this book so much I bought one for every set of cousins on our Christmas list. Our three year old daughter doesn't watch TV so this is a fantastic way for her to get a sense of the wider world....She's fascinated by the photos and stories of the children who dress and live so differently from her. And our older cousins can read the materials themselves. We very enthusiastically recommend this one!
Children Just Like Me
Helpful Votes: 2 out of 2 total.
Review Date: 2007-02-19
Review Date: 2007-02-19
I purchased this book for my son Ben when he was 2 1/2 yrs. old. He is now 10 and my daughter Maria reads it continuously. This book is by far the best young children's awareness book about the differences and similarities between all children on this earth. I work for the YMCA and have purchased it for our summer camp so that the children coming to stay at Camp Silver Beach can learn more about the childhoods of the international counselors who are role models for them during the summer. At 2 1/2 years, my son knew the continents and could point out where "Ari or Celena" lived and tell me their favorite toys or food and point to the countries in which they live. This book is colorful and timeless expanding a child's view of the world and helping to instill the compassion we need to get along with all kinds of people.

The Circus In Winter
Published in Hardcover by (2004-07-05)
List price: $23.00
New price: $4.94
Used price: $4.72
Collectible price: $23.00
Used price: $4.72
Collectible price: $23.00
Average review score: 

I love the circus, but the elephants make me sad.
Helpful Votes: 0 out of 0 total.
Review Date: 2008-03-12
Review Date: 2008-03-12
A friend recommended this to me when I expressed the desire to read a little more about elephants (after reading Philosophy Made Simple and Water for Elephants). It makes sense... elephants and the circus go together, yes?
In this collection, Cathy Day plays with the structures of stories. Each is constructed a little differently than the last, but all interweave to paint a portrait of a small town with a unique past and a distinctly midwestern present. Experimental structures can fall flat as easily as they work. I don't require a linear narrative, but I do require that a story be told. This book tells one.
True to the title, the circus performers are mostly shown during the downtime, weathering winter and waiting to get back on the train. The way that their lives butt up to the lives of ordinary folks is interesting to read about. Several stories deal with the ways in which men do not comprehend the longings of women, and Day handles this theme beautifully and without accusation, especially in The King and His Court and the very tragic The Lone Star Cowboy.
It's a beautiful book. But...
(spoilers)
...the elephants are only shown dying. I can't stand it. Their deep eyes, their hairy hides, their questing trunks, and then they die.
Since the stories are called "exhibits," the question of human oddity ("born" and "made") is called into question. Well, this was part of the circus. One of the stories deals with a young man who has dwarfism, and how he happily accepts the role of town mascot, and what happens when that role is inexplicably (to him) withdrawn. I've read too many stories in which a little person comes in to serve as a metaphor, a symbol, as if somehow a person who has dwarfism is not a person, just the condition that makes him short. Day does a nice job of portraying a person. He is an innocent boy, then a clueless young man, and then an angry young man. He is more than the sum of his bones.
Very highly recommended.
In this collection, Cathy Day plays with the structures of stories. Each is constructed a little differently than the last, but all interweave to paint a portrait of a small town with a unique past and a distinctly midwestern present. Experimental structures can fall flat as easily as they work. I don't require a linear narrative, but I do require that a story be told. This book tells one.
True to the title, the circus performers are mostly shown during the downtime, weathering winter and waiting to get back on the train. The way that their lives butt up to the lives of ordinary folks is interesting to read about. Several stories deal with the ways in which men do not comprehend the longings of women, and Day handles this theme beautifully and without accusation, especially in The King and His Court and the very tragic The Lone Star Cowboy.
It's a beautiful book. But...
(spoilers)
...the elephants are only shown dying. I can't stand it. Their deep eyes, their hairy hides, their questing trunks, and then they die.
Since the stories are called "exhibits," the question of human oddity ("born" and "made") is called into question. Well, this was part of the circus. One of the stories deals with a young man who has dwarfism, and how he happily accepts the role of town mascot, and what happens when that role is inexplicably (to him) withdrawn. I've read too many stories in which a little person comes in to serve as a metaphor, a symbol, as if somehow a person who has dwarfism is not a person, just the condition that makes him short. Day does a nice job of portraying a person. He is an innocent boy, then a clueless young man, and then an angry young man. He is more than the sum of his bones.
Very highly recommended.
A beautiful web.
Helpful Votes: 0 out of 0 total.
Review Date: 2008-02-09
Review Date: 2008-02-09
I've never liked the circus. But this book made me want to learn more about people who live a life tied to it. Day paints beautiful and poignant images of her characters and she weaves a mighty beautiful web in the process.
Delicate and Beautiful
Helpful Votes: 0 out of 0 total.
Review Date: 2008-02-05
Review Date: 2008-02-05
The first stories in this collection are small masterpieces. Cathy Day can take us deep into the secret, hidden hearts of her characters. There were passages that I read, over and over, just to enjoy the beauty of her writing.
It was close to perfect.
I was worried that a 'circus story' would be all about the freaks and geeks. Instead, it was about real people struggling against the loneliness of midwestern winters, coping with broken dreams, the constraints of small town lives, and the endless allure of life on the road.
Sadly, the seams started to show towards the end of the collection. There was nothing bad, so much as a sense of that, in a few of the later stories, she was repeating her best stories (or giving us an early, less polished version of them). One story could have been dropped with no loss ("Jungle Boolah Boy" didn't feel very integrated with the rest of the stories), and another ("Boss Man") felt a bit strained although it did help to tie some of the themes and characters together.
It was close to perfect.
I was worried that a 'circus story' would be all about the freaks and geeks. Instead, it was about real people struggling against the loneliness of midwestern winters, coping with broken dreams, the constraints of small town lives, and the endless allure of life on the road.
Sadly, the seams started to show towards the end of the collection. There was nothing bad, so much as a sense of that, in a few of the later stories, she was repeating her best stories (or giving us an early, less polished version of them). One story could have been dropped with no loss ("Jungle Boolah Boy" didn't feel very integrated with the rest of the stories), and another ("Boss Man") felt a bit strained although it did help to tie some of the themes and characters together.
I do love the circus!
Helpful Votes: 0 out of 0 total.
Review Date: 2006-06-27
Review Date: 2006-06-27
This is a wonderful,short book that I really enjoyed.
The author brings you into the world of circus folks. Sometimes funny,sometimes sad but always interesting. She gives us the story many different ways,which at times can be trying.
Her characters are well fleshed out making you want to know more. She carries thru with this by bringing you from the past to the future and back. A good fun read!
The author brings you into the world of circus folks. Sometimes funny,sometimes sad but always interesting. She gives us the story many different ways,which at times can be trying.
Her characters are well fleshed out making you want to know more. She carries thru with this by bringing you from the past to the future and back. A good fun read!
Read this instead of WATER FOR ELEPHANTS
Helpful Votes: 4 out of 5 total.
Review Date: 2006-12-02
Review Date: 2006-12-02
This book of interconnected short stories related to residents of the old circus town of Lima, Indiana (it's real life counterpart is Peru, Indiana) is just excellent. Great writing, great characterizations and great stories that seem like they could have really happened. Do yourself a favor and read THE CIRCUS IN WINTER instead of WATER FOR ELEPHANTS which is more romance novel than literature but for some unknown reason is reaping a lot of positive buzz.

Coming to Term: Uncovering the Truth About Miscarriage
Published in Hardcover by Houghton Mifflin (2005-01-11)
List price: $24.00
New price: $8.23
Used price: $5.90
Used price: $5.90
Average review score: 

Didn't hold my attention
Helpful Votes: 0 out of 0 total.
Review Date: 2008-07-03
Review Date: 2008-07-03
I was very disappointed with this book. It held my attention for the first 100 pages and afterwards went downhill. I felt I could relate to the stories in the beginning but after that it just seemed like nonsense. I think I was looking for a man to bridge the gap between women & men with miscarriages. Or maybe I was looking for more medical information and what is being done. I defintely did not find either of those topics in this book.
a fast read
Helpful Votes: 0 out of 0 total.
Review Date: 2007-07-18
Review Date: 2007-07-18
I could not put this book down. I found it to be extremely helpful and therapeutic.
Excellent book
Helpful Votes: 0 out of 1 total.
Review Date: 2006-11-14
Review Date: 2006-11-14
This book gave me clarity and peace after suffering from 2 miscarriages. I refer to it often when I need some guidance and explanation. A must for all women who have experienced one or more miscarriages.
Steeped in compassion as well as wisdom and solid information
Helpful Votes: 1 out of 1 total.
Review Date: 2007-12-02
Review Date: 2007-12-02
After his wife miscarried four pregnancies, author Jon Cohen poured effort into assembling a comprehensive, accurate, and user-friendly repository of information on miscarriage. Now in a new paperback edition that corrects a few errors found in the original, Coming to Term: Uncovering the Truth About Miscarriage explores the latest research and findings on the phenomenon, debunks myths and hype, and shines a spotlight on real problems that could be making the occurrence worse in today's world - such as federally unacceptable nitrate levels (which fluctuate seasonally, often influenced by agriculture and animal waste disposal) found in some American wells. Cohen also explores a diverse array of medical treatments, from drugs to surrogate parent contracts to "touchy-feely" emotional therapy methods that can offer surprisingly positive results. Steeped in compassion as well as wisdom and solid information, Coming to Term is highly recommended.
Uncovering the Truth about the Cohen Book
Helpful Votes: 23 out of 37 total.
Review Date: 2006-08-03
Review Date: 2006-08-03
There are several reasons why this book does not deserve its present "five star" rating which are explained in this detailed review. The primary criticism is that the author demonstrates a lack of understanding of the scientific literature. He also shows a lack of scientific insight, and fails to recognize how immune issues can play a role in reproductive failure. He also uses a (now widely considered) flawed study to support his central arguments. Finally, he criticizes reproductive immunologists for their use of anecdotal evidence, yet relies on heavily anecdotal evidence to support his own views. In more detail, here are the weaknesses in this book:
On IVIG treatment for recurrent miscarriage
Cohen chooses to elaborate on the negative sides of the IVIG argument, yet fails to elaborate on the positive arguments, a disservice to the reading, investigating audience trying to understand all sides of IVIG issue.
For example, he agrees that elevated natural killer cell levels can be associated with miscarriage. On page 95, he says: "...studies suggest that women who repeatedly miscarry chromosomally normal babies produce higher level of natural killer cells." Cohen also agrees that IVIG may suppress natural killer cells. Page 95: "Some experiments show that IVIG suppresses natural killer cells" Yet, despite his acceptance of an NK miscarriage connection, he still chooses to scare patients away from lifesaving IVIG treatment that many clinics offer. On page 95 Cohen says "IVIG inadvertently infected people with hepatitis C" and "no amount of screening can test for a pathogen that science has yet to discover." Also, Cohen fails to mention the fact that modern IVIG preparations are screened for all known viruses, past and present. And fails to emphasize that IVIG is completely FDA-approved and thousands of patients are using it routinely with no ill effect for dozens of common autoimmune diseases. For a professional reporter supposedly reporting all sides of an issue, Cohen's investigation seems surprisingly one-sided.
Finally, Cohen seems to criticize the mental state of any patient choosing the IVIG option. At the end of page 95, he states: "untried options can have an intoxicating effect, leading them (women) to throw caution to the wind." I think Cohen's personal bias against reproductive immunology is clear. His ability to report on IVIG with logic and impartiality is sacrificed.
Th1:Th2 theory
On page 79, Cohen states that Th1:Th2 (immunological rejection) theory is a "hugely controversial hypothesis." However, most people who read scientific reproductive journals today would wonder how Cohen arrived at this understanding of the miscarriage literature. If he had a proper grasp of current theory he would not see that the Th1:Th2 theory is not only not "hugely controversial," but it is actually one of the freshest and most accepted new research developments in reproductive immunology medicine today.
How does Cohen arrive at his "Th1:Th2 is controversial" conclusion? In the book, Cohen cites only one single Th1:Th2 review study by Laird SM et al. (he apparently ignores the rest of the rest of the supporting studies in the literature) Yet, interestingly, upon reading carefully, this study actually seems to support Th1:Th2 relevance to miscarriage. It states: "Immunological rejection of the fetus due to recognition of paternal antigens by the maternal immune system, resulting in abnormal immune cells and cytokine production, is postulated to be one cause of unexplained pregnancy loss...there is some evidence for an alteration in the ratio of Th1 and Th2 cytokines produced by peripheral blood monocytes."
Note the phrases: "evidence for an alteration in the ratio of Th1 and Th2 cytokines" may be the "cause of unexplained pregnancy loss." So Cohen's strongest study against Th1: Th2 theory actually seems like it does not bolster his argument much at all?
Antiphospholipid Antibody (APA) Issues
On page 96, Cohen implies that APA positive recurrent miscarriage patients are like a "Black Swans" meaning that, although these patients exist, they are not as common as people might think like (they are rare and over-sensationalized). Again, it appears Cohen is "off the mark" here too. In fact, any layperson who does a cursory Pub-Med search through the literature would find that APA miscarriage patients are actually very common in the recurrent miscarriage population. In fact, one study shows that APA positive patients are present in almost a third of ladies who suffer unexplained recurrent abortion. See study by Cubillos J et al, Incidence of autoantibodies in the infertile population." Obstet Gynecol. 1997 Sep;90 (3):364-9 which states: "In the group of patients with a history of miscarriage, 38.2% (p < 0.05) (tested positive) for APL."
In addition to failing to state the truth about APA frequency, Cohen fails to address the fact that very few centers do the proper APA testing. This may account for why so many APA patients are missed in many infertility clinics. Few local laboratories test for all 6 classes of APA, causing many APA positive patients to be missed: See study by Coulam CB et al: Antiphospholipid antibodies associated with implantation failure after IVF/ET. J Assist Reprod Genet. 1997 Nov;14 (10):603-8. Study quote: "A complete APA panel using seven isotypes is necessary for diagnosing implantation failure associated with RAFS. If only anticardiolipin antibody is measured, 4% (13/312) of the positive APAs are detected, and 81% (56/69) of women with implantation failure associated with RAFS will have the diagnosis missed." Cohen never addresses any of this.
Endometriosis
On page 44, Cohen asserts that no miscarriage/endometriosis connection exists.
Cohen's words: "...controlled, randomized prospective trials later convincingly showed that no such connection exists." However, the truth is, there are dozens of studies in the literature citing the connection between endometriosis to immune issues early pregnancy loss. Does Cohen simply not know these studies exist? Or just he just over-look these studies, instead? Doesn't Cohen ever wonder about the "coincidence" that endometriosis is closely tied to immune issues and is also connected to recurrent pregnancy loss? Has he ever thought that there may possibly be a connection between endometriosis and miscarriage? Once again, Cohen seems naive to the literature and totally naïve to the larger interrelated implications that individual, so-called "unrelated" studies can present. Not only do Cohen's assertions about endometriosis seem naïve, but his assertions seem weak as well. His arguments are based on one single study: Vercammen EE et al: Endometriosis and recurrent pregnancy loss. Semin Reprod Med. 2000;18(4):363-8.
Upon reading the fine print of the study, you find that the argument against the recurrent miscarriage/endometriosis connection is not even that strong to begin with. The authors (countering what Cohen might imply) actually suggest that endometriosis is associated with implantation failure...yes... the very study Cohen uses as his argument against such a connection makes such a connection! See study quote: "...some studies have shown that the decreased number and quality of oocytes, the fertilization rate, and the implantation rate per embryo may be reduced in women with endometriosis"
The Polycystic Ovary Syndrome Issue
On page 114, Cohen states "The largest studies to date of pregnant women with PCOS estimate miscarriage rates of 40 percent and 60 percent." Yet, Cohen misses the connection between PCOS miscarriages and immune issues completely. There is one important immune-PCOS study that he omits entirely by Jakubowicz DJ et al: Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. J. Clin Endocrinol Metab. 2004 Feb;89 (2):833-9. Study quote: "These findings are significant in that they may provide a mechanism for first-trimester miscarriage in PCOS. Because glycodelin inhibits mixed lymphocyte reaction and natural killer cell activity, impaired production of glycodelin presumably allows a maternal immune response against the embryo." Cohen misses the PCOS immune connection completely.
Incompetent Cervix
Cohen's lack of understanding of the miscarriage literature comes through again in discussions about incompetent cervix as well. On page 138, he states "factors that cause the cervix to weaken largely remain a mystery." Yet he also says "some studies have shown links to other uterine anomalies, exposure to DES, and even antiphospholipid antibodies"
Why doesn't Cohen dig deeper here? If indeed he says incompetent cervix is linked to APAS, DES and uterine anomalies, how has he missed the fact that cervical incompetence is also associated with Th1:Th2 cytokine imbalance and that Th1: Th2 cytokine imbalances is associated with incompetent cervix? Doesn't he want to solve this cervical incompetence (as he puts it) "mystery"?
See supporting incompetent cervix studies that Cohen completely misses in his book:
1. Mohapeloa H et al HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage. Hum Reprod. 1998 Apr;13(4):1079-82.
"The results suggest that HLA-DR-associated immunological factors might play a part in recurrent late spontaneous abortions and extremely preterm births under a cervical incompetence-like picture, at least in the subset of cases not treatable by cervical cerclage."
2. Lee KY et al: Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. Am J Obstet Gynecol. 2004 Sep;191(3):784-9.
"Amniotic fluid interleukin-6 is increased in patients with cervical incompetence, which suggests that subclinical inflammation may contribute to cervical incompetence. Further, an elevated interleukin-6 level predicts a cerclage short-latency interval between cerclage and delivery. In contrast with interleukin-6, amniotic fluid relaxin does not appear to contribute to cervical incompetence-induced cervical dilation."
DES immune connection
Also, Cohen misses the fact that families who have used DES to prevent miscarriage may indeed have a higher incidence of immune issues (causing the miscarriages) that this "family tendency" to immune issues may be why "DES daughters" have more miscarriages, not the fact that they have been exposed to the DES in the womb? This possibility is never even considered, brought up or discussed in the book. Cohen, again, fails to address the possible immune connections in families who have used DES, leaving the total DES discussion more confused, not less.
Environment
On page 172, Cohen seems to agree that a few environmental factors may affect pregnancy outcome in certain instances: Nitrates in well water (page 172), and Bisphenol A in plastics (page 173). Nonetheless, Cohen seems uninterested in following up with these studies, he instead still prefers to dismiss the environmental idea overall. On page 174: "... miscarriages, as far as science can now determine, rarely occur because of what a woman eats or drinks, where she lives and works, and what air she breathes."
In fact, Cohen uses a (frankly, ridiculous) description as an example of pregnancy environmental durability: he describes how his grandmother jumped repeatedly off a chair in an attempt to induce a miscarriage. (page 174) This anecdote is (somehow?) used to support the idea that "the uterus, amniotic sac, and the placenta marvelously work together to prevent harm." Quite frankly, this is an embarrassing example of the typically non-scientific arguments that Cohen uses to support his journalistic angles.
Infection
Similarly, Cohen uses faulty logic when he discusses infectious agents. He admits that certain infections possibly may increase the incidence of miscarriage: page 166: "Infection may cause miscarriage "...rubella, syphilis, genital herpes, mumps, toxoplasmosis, malaria, possibly gardenerella." Yet, despite conceding this, Cohen still manages to glide over the infection/immune problem connection. (page 166: "...a few pathogens may account for a small percentage of miscarriages, although their sporadic nature means they play no important role in recurrent loss.")
In addition to pushing the infection miscarriage connection "under the table", Cohen never mentions how infectious agents may possibly stimulate the immune system to cause immune related miscarriage? In fact, the infection- immune connection is never even addressed at all? This is a glaring fault in Cohen's research, especially considering the fact there are several studies implicating the immune system as the ultimate cause of infection-related miscarriage. In fact, Dr Attila Toth of New York City has devoted whole career to this infection/miscarriage issue. Yet apparently Cohen knows nothing of Dr. Toth's research? Or if he does, Cohen chooses not to discuss it? A few infection -immune studies that Cohen misses:
1. Korbel DS et al: Natural killer cells and innate immunity to protozoan pathogens. Int J Parasitol. 2004 Dec;34(13-14):1517-28.
"Natural killer (NK) cells are lymphoid cells that mediate significant cytotoxic activity and produce high levels of pro-inflammatory cytokines in response to infection."... "NK derived interferon-gamma (IFN-gamma) production is also essential for control of several protozoal infections including toxoplasmosis, trypanosomiasis, leishmaniasis and malaria."
2. Ashkar AA et al: "Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection." J Virol. 2003 Sep;77(18):10168-71. "This study demonstrates that IL-15 and NK-NKT cells are critical for innate protection against genital HSV-2."
3. Jensen JR et al: Fluctuations in natural killer cell activity in early syphilis. Br J Vener Dis. 1983 Feb;59(1):30-2. "In primary syphilis natural killer cell activity was increased, especially in patients lacking circulating lipoidal antibodies."
Luteal phase defect and progesterone
In addition to missing the infection-immune connection completely, Cohen also seems to miss the hormonal-immune connection as well. Though he says that an association may exist between luteal phase defect and miscarriage, Cohen misses (yet again) the possible immune relationship that may exist between these two issues. On page 99, Cohen states: "If the lining becomes inhospitable too early, as happens with what's called a deficient luteal phase, the embryo will not burrow, leading to a miscarriage, or it will not borrow currently, causing preeclampsia later in pregnancy"
No discussion is made about the fact that patients with poor luteal phases often have low progesterone in the latter half of the cycle...or the fact that progesterone has been shown to have an immunosuppressive effect. This immune factor may contribute at least in part to progesterone supplement's immune healing effect in recurrent miscarriage patients. See more studies that Cohen apparently misses in his book:
1. Szekeres-Bartho J. Immunological relationship between the mother and the fetus. Int Rev Immunol. 2002 Nov-Dec;21(6):471-95. "Another protective mechanism operating in favor of pregnancy is progesterone-dependent immunomodulation. Due to stimulation by fetally derived antigens, pregnancy lymphocytes develop progesterone receptors and in the presence of progesterone produce a mediator (PIBF) that, through altering the cytokine balance, inhibits NK activity and exerts an antiabortive effect in mice."
2. Laskarin G, Tokmadzic VS, Strbo N, Bogovic T, Szekeres-Bartho J, Randic L, Podack ER, Rukavina D.Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am J Reprod Immunol. 2002 Oct;48(4):201-9. "The results indicate possible role for PIBF, as a mediator of progesterone in regulation of Decidual Lymphocyte cytolytic activity at the maternal-foetal (M-F) interface."
Preeclampsia
Lastly, on page 99, Cohen successfully makes the connection that patients who suffer from luteal phase defect may also suffer from preeclampsia at a higher rate. However (yet again) he totally misses the possible connection that exists between preeclampsia and immune issues (even more surprising considering the number of studies supporting the preeclampsia- immune connection that exist out there). How can Cohen miss this? Again and again it seems Cohen is totally unable to put the complex pieces of the miscarriage puzzle together. Again and again he fails to see the immune connection, failing to see how it can clarify so much of the "muddy water" that exists in this recurrent miscarriage field today. Here are some more immune/reproductive studies that Cohen completely misses:
1.Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol. 2003 Aug;59(2):161-73. "Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation."
2. Makhseed M, Raghupathy R, El-Shazly S, Azizieh F, Al-Harmi JA, Al-Azemi MM. Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol. 2003 May;49(5):308-18.
"These data are suggestive of a maternal type 1 cytokine bias in preterm delivery".
3. Simhan HN, Krohn MA, Zeevi A, Daftary A, Harger G, Caritis SN. Tumor necrosis factor-alpha promoter gene polymorphism -308 and chorioamnionitis. Obstet Gynecol. 2003 Jul;102(1):162-6.
"Carriage of the TNFA2 allele is associated with a more than three-fold increased risk of clinical chorioamnionitis, even when accounting for important clinical and microbiologic risk factors."
4. Kaplan D. Fetal wastage in patients with rheumatoid arthritis. J Rheumatol. 1986 Oct;13(5):875-7.
"Ninety-six women with rheumatoid arthritis (RA) were found to have an abortion ratio higher than that of a comparison group (p = 0.005). This was true even before the onset of their RA (p = 0.007)"
5. Sergent F, Verspyck E, Marpeau L. [Crohn's disease and pregnancy. About 34 cases. Review of the literature] Gynecol Obstet Fertil. 2003 Jan;31(1):20-8.
"When the disease (Crohn's) is active, the risk of abortion and prematurity increases."
3. Cohen's flawed anti LIT arguments
Gullible patients
On page 58 Cohen begins: "Many couples plug their ears and firmly believe that because of the treatment, they have babies - and no amount of scientific data can shake the power of that conviction." From the beginning of the book, Cohen seems step off on the wrong foot about a typical reproductive immunology patient's psychological nature. He apparently accusing anyone who choose new or controversial treatments (like LIT or IVIG) to be emotionally gullible, unwilling (or unable?) to make sound scientific decisions. In fact, in my personal experience (through my many years watching these types of treatment programs) I have found that reproductive immunology (RI) patients are probably some of the most clear thinking, well read, well researched medical patients out there, able to pull apart any study to find its strengths, weaknesses and its flaws. Certainly most RI patients are not types to ignore solid scientific data. Already Cohen seems "off base" about the patient population he is writing about.
The REMIS LIT study by Carol Ober
Regarding the Carol Ober REMIS study Cohen states on page 69: "Because of the lack of benefit, we recommend against this intervention (LIT) as a treatment for unexplained recurrent miscarriage' concluded the researchers." It is already known that the REMIS study "proving" LIT ineffective was flawed in many ways. Dr. Beer outlined these flaws in detail in his Letter to the Editor sent to the Lancet. Among the REMIS study flaws that Dr. Beer cites are:
1. Failure to recruit an adequate number of study patients.
2. Failure to induce immune responses. Only 26% of women who received lymphocyte immunization developed HLA antibody response. (The immunization must have been prepared and/or given incorrectly to elicit this low response.)
3. 21 of 59 abortuses received genetic study. All (total 11) abnormal fetuses were from treatment group but this data was not reflected in the outcome analysis.
4. A higher proportion of treatment group had a previous live birth (P=0.054). Yet a previous meta-analysis had shown that lymphocyte immunization more effective in women with primary abortions. This was not discussed or considered in the REMIS study.
I know Cohen, through his LIT research, must have read the miscarriage support sites and Dr Beer's Lancet letter (available online to anybody), yet he makes no mention of this letter or any of its arguments in his LIT chapter. Why does he seem to avoid addressing this issue? This reporting bias not only does injustice the LIT, but also to those trying to find the truth about this LIT medicine. And frankly makes one wonder about how "impartial" Cohen's journalistic intentions really are.
Poor patient selection
Many of Dr. Beer's criticisms of the REMIS study similarly apply to other LIT studies. A common flaw found in negative outcome LIT studies is the failure to test subject's LAD (blocking antibody) levels before and after the LIT injections. As a result, researchers never really know if LIT patient:
1. Really needs LIT
2. Has achieved a proper LIT response before conception is attempted
In addition to these flaws, some LIT studies fail to use fresh donor cells (such as the REMIS study), making LIT less effective. Other studies fail to follow the timing and dose requirements that Dr. Beer recommends (i.e. some studies only do LIT once preconception, some studies do not wait the 3- 4 weeks necessary for the proper immune response take place). Lastly, those who understand reproductive immunology understand that LIT should be not be used as the sole immune treatment. Other immune problems need to be identified and independently treated as well (e.g. APA issues, ANA issues, cytokine imbalance, etc). Essentially, patients need a full immune work-up before doctors decide how LIT will fit into their total immune protocol. See Christiansen et al: Evidence-based investigations and treatments of recurrent pregnancy loss. Fertility and Sterility, Volume 83, Issue 4, April 2005, pages 821-839. Study quote: "Current meta-analyses evaluating the efficacy of treatments of RPL are generally pooling very heterogeneous patient populations and treatments. It is recommended that future meta-analyses look at subsets of patients and treatment protocols that are more combinable."
Cohen criticizes the use of anecdotal evidence yet uses anecodotal evidence himself
On page 74 Cohen criticizes the LIT studies as being flawed saying, "the fuzzy scientific rationale behind theories often makes it difficult to select patients who indeed may benefit from a treatment." Yet at the end of the same chapter, on page 82, he uses the example of a solitary successful pregnancy (Jess') that succeeded without LIT use, saying this success "casts further doubts about whether the value of lymphocyte immune therapy"
So Cohen uses one solitary pregnancy success to "further cast doubts" on the value of LIT? He admits the success is anecdotal, yet still uses it as an emotional tool to bash LIT at the end of his chapter. Again Cohen seems to push non-scientific thinking here. How are readers supposed to respect the author as a scientifically unbiased journalist when so much emphasis is placed on the emotional power of the single success story, to pull the emotions of the reader at the end?
Also, it should be noted, if Cohen had any true understanding of LIT, he would recognize that blocking antibodies built of from Jess's previous successful pregnancy would have alone explained her second pregnancy success without LIT. Yet this possibility is not even touched upon in the chapter because Cohen apparently does not understand the LIT science (either "does not understand" the issue or chooses to skip over the issue altogether?) In either case, from a reproductive immunologist's point of view, this LIT chapter ends on a very weak note.
The Tender Loving Care (TLC) argument
Last but not least, we must talk about the author's focus on "Tender Loving Care" (TLC) Cohen's "beloved" argument that he seems to like to use to dilute the validity of many miscarriage studies in the book. Throughout the book, it is evident that Cohen has been rather "sucked in" by the Tender Loving Care argument, the idea that offering extensive psychological support and emotional support to a patient can significantly increase a patient's likelihood of pregnancy success.
On page 175, Cohen calls the Liddell TLC study, "a study with spectacular powers." In a RESOLVE Interview Cohen calls Dr. Lesley Regan's 1997 TLC study "an amazing study. I learned more from it than maybe any single paper (and I have read maybe1000). I highly recommend it." Essentially Cohen has three studies to back his TLC argument:
1. Liddell HS et al: Recurrent miscarriage--outcome after supportive care in early pregnancy. : Aust N Z J Obstet Gynaecol. 1991 Nov;31(4):320-2.
86% success with TLC (38/44)
33% success without TLC (3/9)
2. Clifford K et al: Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod. 1997 Feb;12(2):387-9.
74% success with TLC (118/160)
49% success no TLC (20/41)
3. Stray-Pedersen B et al: Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol. 1984 Jan 15;148(2):140-6.
86% success TLC (no actual pregnancy numbers given in this abstract)
33% with no TLC
At first glance, these success numbers seem surprising, even shocking and impressive considering the "vague", "touchy-feely" nature of the TLC subject matter. But looking deeper in the methodology of these studies, we find the statistics are probably more deceiving and more flawed than we know. First, all the patients in each of these studies were "self selected" to receive TLC from the clinic. Populations were not randomized at all, which, of course, is a Big Red Flag to anyone trying to get meaningful scientific results. So you have to ask yourself, given the fact these TLC populations are "self selected", what reasons could cause one patient to "select" to discontinue medical care while another patient chooses to continue it? Could it be that patients whose pregnancies succeed may be more inclined to stay with the clinic, while those that are having negative experiences tend to drop out of a program with higher frequency? This is not TLC are we are measuring here. It could be a measurement of an interesting tendency to "hide" and "grieve" in human nature.
Also, another point to note about these TLC studies: in not one of these TLC studies is the actual "Tender Loving Care" procedure exactly outlined. What does this TLC actually involve physically? There may be factors involved in these TLC pregnancy successes apart from the TLC itself, factors we could never pick up on because they are not outlined for us? This description deficiency is yet another red flag with these studies.
Dr. Beer's success due to TLC?
Last, but not least, it appears that Cohen sees Dr Beer's program through "TLC tinted glasses" as well. See Cohen's quote on page 82: "I suspect that he (Dr. Beer) does offer tender-loving care, and that its benefits may confuse the results his patients experience with experimental treatments." In making this statement, Cohen clearly reveals his lack of familiarity with the day to day running of Dr. Beer's program. One thing most of Beer patients know, only a small percentage of Dr. Beer's registered patients actually ever meet Dr. Beer in person. Most of Dr. Beer's consults are conducted by phone or by email. In fact, Dr. Beer only meets about 5% of his registered patients "in person" at all. Many of these patient meetings are "one time only" personal meetings with later consults being done over the phone or through email. Certainly, Dr. Beer does not have ongoing basis face to face relationship with most of his patients, unless one considers emails "TLC." All in all, Cohen puts these TLC studies on a pedestal in a way he rarely does with other studies in the book. Cohen's later words about the TLC studies are even more revealing:
Page 179: "Just as scientific research can never prove that love exists, I suspect it can never arrive at rock solid evidence that expert care prevents miscarriage or helps people come to terms with their reproductive fate. But as one researcher said to me, If you witness a talking dog, you do not need a control group to believe it. In three different recurrent miscarriage clinics around the world, I have seen the equivalent of a talking dog"
How can you argue with someone who has decided that controlled studies are no longer necessary to prove a theory valid? This is the same man who says we should dismiss LIT because the studies are flawed? A man who believes that TLC is as obvious because it is like a "talking dog"? It scares me, frankly, that Cohen is writing a book we are supposed to take seriously, that the world is supposed to take seriously, when he openly admits to using a "talking dog" type of reasoning.
Finally, Cohen's most heartfelt speech in his book, making the strongest veiled attacks on any miscarriage patient's decision to use immune therapy are found on page 129: "Women and men who want babies, especially those who have tried and failed, would benefit if they recognized how intense desires can lead them to take unnecessary risks. It bears repeating again and again and again. Most women who miscarry even three or four times, will carry to term if they become pregnant again...they (millions of women) may logically end up in the delivery room praising an intervention that, years later, they will come to curse." What does this mean, praising an intervention "in the delivery room" that, years later, "they will come to curse"? Does this mean, even after delivering our "Beer babies" using immunotherapy, we will feel we made the wrong decision to do LIT and IVIG? Please! I just hope that others can see through the facade of this book the way that I do.
As I hold and play with my "Beer babies" each day, after suffering devastating losses, I feel blessed that I myself, at least I have put the scientific connections together. That I, myself, at least, have seen the patterns, seen the immune connections, as a result, understand the bigger miscarriage picture in a much more complete way.
Pity those who read this book and come away feeling more confused about immune therapies than they were before. Pity them. Pity Cohen for bringing this situation about. However, in the big picture, I am not worried. I honestly feel that so much progress has been made in this reproductive immunology field the last few years, that the blind, anecdotally-based musings of a sensationalist reporter will do nothing to hurt the field over the long term. The foundation of the RI science is far too reaching, far too strong to ever be marred by the non-scientific ponderings that are really so biased that most (if not all) true scientists will see right through them upon reading this very dangerously naïve and misleading book.
-An informed RI Advocate and Dr Beer patient
On IVIG treatment for recurrent miscarriage
Cohen chooses to elaborate on the negative sides of the IVIG argument, yet fails to elaborate on the positive arguments, a disservice to the reading, investigating audience trying to understand all sides of IVIG issue.
For example, he agrees that elevated natural killer cell levels can be associated with miscarriage. On page 95, he says: "...studies suggest that women who repeatedly miscarry chromosomally normal babies produce higher level of natural killer cells." Cohen also agrees that IVIG may suppress natural killer cells. Page 95: "Some experiments show that IVIG suppresses natural killer cells" Yet, despite his acceptance of an NK miscarriage connection, he still chooses to scare patients away from lifesaving IVIG treatment that many clinics offer. On page 95 Cohen says "IVIG inadvertently infected people with hepatitis C" and "no amount of screening can test for a pathogen that science has yet to discover." Also, Cohen fails to mention the fact that modern IVIG preparations are screened for all known viruses, past and present. And fails to emphasize that IVIG is completely FDA-approved and thousands of patients are using it routinely with no ill effect for dozens of common autoimmune diseases. For a professional reporter supposedly reporting all sides of an issue, Cohen's investigation seems surprisingly one-sided.
Finally, Cohen seems to criticize the mental state of any patient choosing the IVIG option. At the end of page 95, he states: "untried options can have an intoxicating effect, leading them (women) to throw caution to the wind." I think Cohen's personal bias against reproductive immunology is clear. His ability to report on IVIG with logic and impartiality is sacrificed.
Th1:Th2 theory
On page 79, Cohen states that Th1:Th2 (immunological rejection) theory is a "hugely controversial hypothesis." However, most people who read scientific reproductive journals today would wonder how Cohen arrived at this understanding of the miscarriage literature. If he had a proper grasp of current theory he would not see that the Th1:Th2 theory is not only not "hugely controversial," but it is actually one of the freshest and most accepted new research developments in reproductive immunology medicine today.
How does Cohen arrive at his "Th1:Th2 is controversial" conclusion? In the book, Cohen cites only one single Th1:Th2 review study by Laird SM et al. (he apparently ignores the rest of the rest of the supporting studies in the literature) Yet, interestingly, upon reading carefully, this study actually seems to support Th1:Th2 relevance to miscarriage. It states: "Immunological rejection of the fetus due to recognition of paternal antigens by the maternal immune system, resulting in abnormal immune cells and cytokine production, is postulated to be one cause of unexplained pregnancy loss...there is some evidence for an alteration in the ratio of Th1 and Th2 cytokines produced by peripheral blood monocytes."
Note the phrases: "evidence for an alteration in the ratio of Th1 and Th2 cytokines" may be the "cause of unexplained pregnancy loss." So Cohen's strongest study against Th1: Th2 theory actually seems like it does not bolster his argument much at all?
Antiphospholipid Antibody (APA) Issues
On page 96, Cohen implies that APA positive recurrent miscarriage patients are like a "Black Swans" meaning that, although these patients exist, they are not as common as people might think like (they are rare and over-sensationalized). Again, it appears Cohen is "off the mark" here too. In fact, any layperson who does a cursory Pub-Med search through the literature would find that APA miscarriage patients are actually very common in the recurrent miscarriage population. In fact, one study shows that APA positive patients are present in almost a third of ladies who suffer unexplained recurrent abortion. See study by Cubillos J et al, Incidence of autoantibodies in the infertile population." Obstet Gynecol. 1997 Sep;90 (3):364-9 which states: "In the group of patients with a history of miscarriage, 38.2% (p < 0.05) (tested positive) for APL."
In addition to failing to state the truth about APA frequency, Cohen fails to address the fact that very few centers do the proper APA testing. This may account for why so many APA patients are missed in many infertility clinics. Few local laboratories test for all 6 classes of APA, causing many APA positive patients to be missed: See study by Coulam CB et al: Antiphospholipid antibodies associated with implantation failure after IVF/ET. J Assist Reprod Genet. 1997 Nov;14 (10):603-8. Study quote: "A complete APA panel using seven isotypes is necessary for diagnosing implantation failure associated with RAFS. If only anticardiolipin antibody is measured, 4% (13/312) of the positive APAs are detected, and 81% (56/69) of women with implantation failure associated with RAFS will have the diagnosis missed." Cohen never addresses any of this.
Endometriosis
On page 44, Cohen asserts that no miscarriage/endometriosis connection exists.
Cohen's words: "...controlled, randomized prospective trials later convincingly showed that no such connection exists." However, the truth is, there are dozens of studies in the literature citing the connection between endometriosis to immune issues early pregnancy loss. Does Cohen simply not know these studies exist? Or just he just over-look these studies, instead? Doesn't Cohen ever wonder about the "coincidence" that endometriosis is closely tied to immune issues and is also connected to recurrent pregnancy loss? Has he ever thought that there may possibly be a connection between endometriosis and miscarriage? Once again, Cohen seems naive to the literature and totally naïve to the larger interrelated implications that individual, so-called "unrelated" studies can present. Not only do Cohen's assertions about endometriosis seem naïve, but his assertions seem weak as well. His arguments are based on one single study: Vercammen EE et al: Endometriosis and recurrent pregnancy loss. Semin Reprod Med. 2000;18(4):363-8.
Upon reading the fine print of the study, you find that the argument against the recurrent miscarriage/endometriosis connection is not even that strong to begin with. The authors (countering what Cohen might imply) actually suggest that endometriosis is associated with implantation failure...yes... the very study Cohen uses as his argument against such a connection makes such a connection! See study quote: "...some studies have shown that the decreased number and quality of oocytes, the fertilization rate, and the implantation rate per embryo may be reduced in women with endometriosis"
The Polycystic Ovary Syndrome Issue
On page 114, Cohen states "The largest studies to date of pregnant women with PCOS estimate miscarriage rates of 40 percent and 60 percent." Yet, Cohen misses the connection between PCOS miscarriages and immune issues completely. There is one important immune-PCOS study that he omits entirely by Jakubowicz DJ et al: Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. J. Clin Endocrinol Metab. 2004 Feb;89 (2):833-9. Study quote: "These findings are significant in that they may provide a mechanism for first-trimester miscarriage in PCOS. Because glycodelin inhibits mixed lymphocyte reaction and natural killer cell activity, impaired production of glycodelin presumably allows a maternal immune response against the embryo." Cohen misses the PCOS immune connection completely.
Incompetent Cervix
Cohen's lack of understanding of the miscarriage literature comes through again in discussions about incompetent cervix as well. On page 138, he states "factors that cause the cervix to weaken largely remain a mystery." Yet he also says "some studies have shown links to other uterine anomalies, exposure to DES, and even antiphospholipid antibodies"
Why doesn't Cohen dig deeper here? If indeed he says incompetent cervix is linked to APAS, DES and uterine anomalies, how has he missed the fact that cervical incompetence is also associated with Th1:Th2 cytokine imbalance and that Th1: Th2 cytokine imbalances is associated with incompetent cervix? Doesn't he want to solve this cervical incompetence (as he puts it) "mystery"?
See supporting incompetent cervix studies that Cohen completely misses in his book:
1. Mohapeloa H et al HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage. Hum Reprod. 1998 Apr;13(4):1079-82.
"The results suggest that HLA-DR-associated immunological factors might play a part in recurrent late spontaneous abortions and extremely preterm births under a cervical incompetence-like picture, at least in the subset of cases not treatable by cervical cerclage."
2. Lee KY et al: Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. Am J Obstet Gynecol. 2004 Sep;191(3):784-9.
"Amniotic fluid interleukin-6 is increased in patients with cervical incompetence, which suggests that subclinical inflammation may contribute to cervical incompetence. Further, an elevated interleukin-6 level predicts a cerclage short-latency interval between cerclage and delivery. In contrast with interleukin-6, amniotic fluid relaxin does not appear to contribute to cervical incompetence-induced cervical dilation."
DES immune connection
Also, Cohen misses the fact that families who have used DES to prevent miscarriage may indeed have a higher incidence of immune issues (causing the miscarriages) that this "family tendency" to immune issues may be why "DES daughters" have more miscarriages, not the fact that they have been exposed to the DES in the womb? This possibility is never even considered, brought up or discussed in the book. Cohen, again, fails to address the possible immune connections in families who have used DES, leaving the total DES discussion more confused, not less.
Environment
On page 172, Cohen seems to agree that a few environmental factors may affect pregnancy outcome in certain instances: Nitrates in well water (page 172), and Bisphenol A in plastics (page 173). Nonetheless, Cohen seems uninterested in following up with these studies, he instead still prefers to dismiss the environmental idea overall. On page 174: "... miscarriages, as far as science can now determine, rarely occur because of what a woman eats or drinks, where she lives and works, and what air she breathes."
In fact, Cohen uses a (frankly, ridiculous) description as an example of pregnancy environmental durability: he describes how his grandmother jumped repeatedly off a chair in an attempt to induce a miscarriage. (page 174) This anecdote is (somehow?) used to support the idea that "the uterus, amniotic sac, and the placenta marvelously work together to prevent harm." Quite frankly, this is an embarrassing example of the typically non-scientific arguments that Cohen uses to support his journalistic angles.
Infection
Similarly, Cohen uses faulty logic when he discusses infectious agents. He admits that certain infections possibly may increase the incidence of miscarriage: page 166: "Infection may cause miscarriage "...rubella, syphilis, genital herpes, mumps, toxoplasmosis, malaria, possibly gardenerella." Yet, despite conceding this, Cohen still manages to glide over the infection/immune problem connection. (page 166: "...a few pathogens may account for a small percentage of miscarriages, although their sporadic nature means they play no important role in recurrent loss.")
In addition to pushing the infection miscarriage connection "under the table", Cohen never mentions how infectious agents may possibly stimulate the immune system to cause immune related miscarriage? In fact, the infection- immune connection is never even addressed at all? This is a glaring fault in Cohen's research, especially considering the fact there are several studies implicating the immune system as the ultimate cause of infection-related miscarriage. In fact, Dr Attila Toth of New York City has devoted whole career to this infection/miscarriage issue. Yet apparently Cohen knows nothing of Dr. Toth's research? Or if he does, Cohen chooses not to discuss it? A few infection -immune studies that Cohen misses:
1. Korbel DS et al: Natural killer cells and innate immunity to protozoan pathogens. Int J Parasitol. 2004 Dec;34(13-14):1517-28.
"Natural killer (NK) cells are lymphoid cells that mediate significant cytotoxic activity and produce high levels of pro-inflammatory cytokines in response to infection."... "NK derived interferon-gamma (IFN-gamma) production is also essential for control of several protozoal infections including toxoplasmosis, trypanosomiasis, leishmaniasis and malaria."
2. Ashkar AA et al: "Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection." J Virol. 2003 Sep;77(18):10168-71. "This study demonstrates that IL-15 and NK-NKT cells are critical for innate protection against genital HSV-2."
3. Jensen JR et al: Fluctuations in natural killer cell activity in early syphilis. Br J Vener Dis. 1983 Feb;59(1):30-2. "In primary syphilis natural killer cell activity was increased, especially in patients lacking circulating lipoidal antibodies."
Luteal phase defect and progesterone
In addition to missing the infection-immune connection completely, Cohen also seems to miss the hormonal-immune connection as well. Though he says that an association may exist between luteal phase defect and miscarriage, Cohen misses (yet again) the possible immune relationship that may exist between these two issues. On page 99, Cohen states: "If the lining becomes inhospitable too early, as happens with what's called a deficient luteal phase, the embryo will not burrow, leading to a miscarriage, or it will not borrow currently, causing preeclampsia later in pregnancy"
No discussion is made about the fact that patients with poor luteal phases often have low progesterone in the latter half of the cycle...or the fact that progesterone has been shown to have an immunosuppressive effect. This immune factor may contribute at least in part to progesterone supplement's immune healing effect in recurrent miscarriage patients. See more studies that Cohen apparently misses in his book:
1. Szekeres-Bartho J. Immunological relationship between the mother and the fetus. Int Rev Immunol. 2002 Nov-Dec;21(6):471-95. "Another protective mechanism operating in favor of pregnancy is progesterone-dependent immunomodulation. Due to stimulation by fetally derived antigens, pregnancy lymphocytes develop progesterone receptors and in the presence of progesterone produce a mediator (PIBF) that, through altering the cytokine balance, inhibits NK activity and exerts an antiabortive effect in mice."
2. Laskarin G, Tokmadzic VS, Strbo N, Bogovic T, Szekeres-Bartho J, Randic L, Podack ER, Rukavina D.Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am J Reprod Immunol. 2002 Oct;48(4):201-9. "The results indicate possible role for PIBF, as a mediator of progesterone in regulation of Decidual Lymphocyte cytolytic activity at the maternal-foetal (M-F) interface."
Preeclampsia
Lastly, on page 99, Cohen successfully makes the connection that patients who suffer from luteal phase defect may also suffer from preeclampsia at a higher rate. However (yet again) he totally misses the possible connection that exists between preeclampsia and immune issues (even more surprising considering the number of studies supporting the preeclampsia- immune connection that exist out there). How can Cohen miss this? Again and again it seems Cohen is totally unable to put the complex pieces of the miscarriage puzzle together. Again and again he fails to see the immune connection, failing to see how it can clarify so much of the "muddy water" that exists in this recurrent miscarriage field today. Here are some more immune/reproductive studies that Cohen completely misses:
1.Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol. 2003 Aug;59(2):161-73. "Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation."
2. Makhseed M, Raghupathy R, El-Shazly S, Azizieh F, Al-Harmi JA, Al-Azemi MM. Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol. 2003 May;49(5):308-18.
"These data are suggestive of a maternal type 1 cytokine bias in preterm delivery".
3. Simhan HN, Krohn MA, Zeevi A, Daftary A, Harger G, Caritis SN. Tumor necrosis factor-alpha promoter gene polymorphism -308 and chorioamnionitis. Obstet Gynecol. 2003 Jul;102(1):162-6.
"Carriage of the TNFA2 allele is associated with a more than three-fold increased risk of clinical chorioamnionitis, even when accounting for important clinical and microbiologic risk factors."
4. Kaplan D. Fetal wastage in patients with rheumatoid arthritis. J Rheumatol. 1986 Oct;13(5):875-7.
"Ninety-six women with rheumatoid arthritis (RA) were found to have an abortion ratio higher than that of a comparison group (p = 0.005). This was true even before the onset of their RA (p = 0.007)"
5. Sergent F, Verspyck E, Marpeau L. [Crohn's disease and pregnancy. About 34 cases. Review of the literature] Gynecol Obstet Fertil. 2003 Jan;31(1):20-8.
"When the disease (Crohn's) is active, the risk of abortion and prematurity increases."
3. Cohen's flawed anti LIT arguments
Gullible patients
On page 58 Cohen begins: "Many couples plug their ears and firmly believe that because of the treatment, they have babies - and no amount of scientific data can shake the power of that conviction." From the beginning of the book, Cohen seems step off on the wrong foot about a typical reproductive immunology patient's psychological nature. He apparently accusing anyone who choose new or controversial treatments (like LIT or IVIG) to be emotionally gullible, unwilling (or unable?) to make sound scientific decisions. In fact, in my personal experience (through my many years watching these types of treatment programs) I have found that reproductive immunology (RI) patients are probably some of the most clear thinking, well read, well researched medical patients out there, able to pull apart any study to find its strengths, weaknesses and its flaws. Certainly most RI patients are not types to ignore solid scientific data. Already Cohen seems "off base" about the patient population he is writing about.
The REMIS LIT study by Carol Ober
Regarding the Carol Ober REMIS study Cohen states on page 69: "Because of the lack of benefit, we recommend against this intervention (LIT) as a treatment for unexplained recurrent miscarriage' concluded the researchers." It is already known that the REMIS study "proving" LIT ineffective was flawed in many ways. Dr. Beer outlined these flaws in detail in his Letter to the Editor sent to the Lancet. Among the REMIS study flaws that Dr. Beer cites are:
1. Failure to recruit an adequate number of study patients.
2. Failure to induce immune responses. Only 26% of women who received lymphocyte immunization developed HLA antibody response. (The immunization must have been prepared and/or given incorrectly to elicit this low response.)
3. 21 of 59 abortuses received genetic study. All (total 11) abnormal fetuses were from treatment group but this data was not reflected in the outcome analysis.
4. A higher proportion of treatment group had a previous live birth (P=0.054). Yet a previous meta-analysis had shown that lymphocyte immunization more effective in women with primary abortions. This was not discussed or considered in the REMIS study.
I know Cohen, through his LIT research, must have read the miscarriage support sites and Dr Beer's Lancet letter (available online to anybody), yet he makes no mention of this letter or any of its arguments in his LIT chapter. Why does he seem to avoid addressing this issue? This reporting bias not only does injustice the LIT, but also to those trying to find the truth about this LIT medicine. And frankly makes one wonder about how "impartial" Cohen's journalistic intentions really are.
Poor patient selection
Many of Dr. Beer's criticisms of the REMIS study similarly apply to other LIT studies. A common flaw found in negative outcome LIT studies is the failure to test subject's LAD (blocking antibody) levels before and after the LIT injections. As a result, researchers never really know if LIT patient:
1. Really needs LIT
2. Has achieved a proper LIT response before conception is attempted
In addition to these flaws, some LIT studies fail to use fresh donor cells (such as the REMIS study), making LIT less effective. Other studies fail to follow the timing and dose requirements that Dr. Beer recommends (i.e. some studies only do LIT once preconception, some studies do not wait the 3- 4 weeks necessary for the proper immune response take place). Lastly, those who understand reproductive immunology understand that LIT should be not be used as the sole immune treatment. Other immune problems need to be identified and independently treated as well (e.g. APA issues, ANA issues, cytokine imbalance, etc). Essentially, patients need a full immune work-up before doctors decide how LIT will fit into their total immune protocol. See Christiansen et al: Evidence-based investigations and treatments of recurrent pregnancy loss. Fertility and Sterility, Volume 83, Issue 4, April 2005, pages 821-839. Study quote: "Current meta-analyses evaluating the efficacy of treatments of RPL are generally pooling very heterogeneous patient populations and treatments. It is recommended that future meta-analyses look at subsets of patients and treatment protocols that are more combinable."
Cohen criticizes the use of anecdotal evidence yet uses anecodotal evidence himself
On page 74 Cohen criticizes the LIT studies as being flawed saying, "the fuzzy scientific rationale behind theories often makes it difficult to select patients who indeed may benefit from a treatment." Yet at the end of the same chapter, on page 82, he uses the example of a solitary successful pregnancy (Jess') that succeeded without LIT use, saying this success "casts further doubts about whether the value of lymphocyte immune therapy"
So Cohen uses one solitary pregnancy success to "further cast doubts" on the value of LIT? He admits the success is anecdotal, yet still uses it as an emotional tool to bash LIT at the end of his chapter. Again Cohen seems to push non-scientific thinking here. How are readers supposed to respect the author as a scientifically unbiased journalist when so much emphasis is placed on the emotional power of the single success story, to pull the emotions of the reader at the end?
Also, it should be noted, if Cohen had any true understanding of LIT, he would recognize that blocking antibodies built of from Jess's previous successful pregnancy would have alone explained her second pregnancy success without LIT. Yet this possibility is not even touched upon in the chapter because Cohen apparently does not understand the LIT science (either "does not understand" the issue or chooses to skip over the issue altogether?) In either case, from a reproductive immunologist's point of view, this LIT chapter ends on a very weak note.
The Tender Loving Care (TLC) argument
Last but not least, we must talk about the author's focus on "Tender Loving Care" (TLC) Cohen's "beloved" argument that he seems to like to use to dilute the validity of many miscarriage studies in the book. Throughout the book, it is evident that Cohen has been rather "sucked in" by the Tender Loving Care argument, the idea that offering extensive psychological support and emotional support to a patient can significantly increase a patient's likelihood of pregnancy success.
On page 175, Cohen calls the Liddell TLC study, "a study with spectacular powers." In a RESOLVE Interview Cohen calls Dr. Lesley Regan's 1997 TLC study "an amazing study. I learned more from it than maybe any single paper (and I have read maybe1000). I highly recommend it." Essentially Cohen has three studies to back his TLC argument:
1. Liddell HS et al: Recurrent miscarriage--outcome after supportive care in early pregnancy. : Aust N Z J Obstet Gynaecol. 1991 Nov;31(4):320-2.
86% success with TLC (38/44)
33% success without TLC (3/9)
2. Clifford K et al: Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod. 1997 Feb;12(2):387-9.
74% success with TLC (118/160)
49% success no TLC (20/41)
3. Stray-Pedersen B et al: Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol. 1984 Jan 15;148(2):140-6.
86% success TLC (no actual pregnancy numbers given in this abstract)
33% with no TLC
At first glance, these success numbers seem surprising, even shocking and impressive considering the "vague", "touchy-feely" nature of the TLC subject matter. But looking deeper in the methodology of these studies, we find the statistics are probably more deceiving and more flawed than we know. First, all the patients in each of these studies were "self selected" to receive TLC from the clinic. Populations were not randomized at all, which, of course, is a Big Red Flag to anyone trying to get meaningful scientific results. So you have to ask yourself, given the fact these TLC populations are "self selected", what reasons could cause one patient to "select" to discontinue medical care while another patient chooses to continue it? Could it be that patients whose pregnancies succeed may be more inclined to stay with the clinic, while those that are having negative experiences tend to drop out of a program with higher frequency? This is not TLC are we are measuring here. It could be a measurement of an interesting tendency to "hide" and "grieve" in human nature.
Also, another point to note about these TLC studies: in not one of these TLC studies is the actual "Tender Loving Care" procedure exactly outlined. What does this TLC actually involve physically? There may be factors involved in these TLC pregnancy successes apart from the TLC itself, factors we could never pick up on because they are not outlined for us? This description deficiency is yet another red flag with these studies.
Dr. Beer's success due to TLC?
Last, but not least, it appears that Cohen sees Dr Beer's program through "TLC tinted glasses" as well. See Cohen's quote on page 82: "I suspect that he (Dr. Beer) does offer tender-loving care, and that its benefits may confuse the results his patients experience with experimental treatments." In making this statement, Cohen clearly reveals his lack of familiarity with the day to day running of Dr. Beer's program. One thing most of Beer patients know, only a small percentage of Dr. Beer's registered patients actually ever meet Dr. Beer in person. Most of Dr. Beer's consults are conducted by phone or by email. In fact, Dr. Beer only meets about 5% of his registered patients "in person" at all. Many of these patient meetings are "one time only" personal meetings with later consults being done over the phone or through email. Certainly, Dr. Beer does not have ongoing basis face to face relationship with most of his patients, unless one considers emails "TLC." All in all, Cohen puts these TLC studies on a pedestal in a way he rarely does with other studies in the book. Cohen's later words about the TLC studies are even more revealing:
Page 179: "Just as scientific research can never prove that love exists, I suspect it can never arrive at rock solid evidence that expert care prevents miscarriage or helps people come to terms with their reproductive fate. But as one researcher said to me, If you witness a talking dog, you do not need a control group to believe it. In three different recurrent miscarriage clinics around the world, I have seen the equivalent of a talking dog"
How can you argue with someone who has decided that controlled studies are no longer necessary to prove a theory valid? This is the same man who says we should dismiss LIT because the studies are flawed? A man who believes that TLC is as obvious because it is like a "talking dog"? It scares me, frankly, that Cohen is writing a book we are supposed to take seriously, that the world is supposed to take seriously, when he openly admits to using a "talking dog" type of reasoning.
Finally, Cohen's most heartfelt speech in his book, making the strongest veiled attacks on any miscarriage patient's decision to use immune therapy are found on page 129: "Women and men who want babies, especially those who have tried and failed, would benefit if they recognized how intense desires can lead them to take unnecessary risks. It bears repeating again and again and again. Most women who miscarry even three or four times, will carry to term if they become pregnant again...they (millions of women) may logically end up in the delivery room praising an intervention that, years later, they will come to curse." What does this mean, praising an intervention "in the delivery room" that, years later, "they will come to curse"? Does this mean, even after delivering our "Beer babies" using immunotherapy, we will feel we made the wrong decision to do LIT and IVIG? Please! I just hope that others can see through the facade of this book the way that I do.
As I hold and play with my "Beer babies" each day, after suffering devastating losses, I feel blessed that I myself, at least I have put the scientific connections together. That I, myself, at least, have seen the patterns, seen the immune connections, as a result, understand the bigger miscarriage picture in a much more complete way.
Pity those who read this book and come away feeling more confused about immune therapies than they were before. Pity them. Pity Cohen for bringing this situation about. However, in the big picture, I am not worried. I honestly feel that so much progress has been made in this reproductive immunology field the last few years, that the blind, anecdotally-based musings of a sensationalist reporter will do nothing to hurt the field over the long term. The foundation of the RI science is far too reaching, far too strong to ever be marred by the non-scientific ponderings that are really so biased that most (if not all) true scientists will see right through them upon reading this very dangerously naïve and misleading book.
-An informed RI Advocate and Dr Beer patient

Embracing Fear: and Finding the Courage to Live Your Life
Published in Hardcover by Amazon Remainders Account (2002-04-30)
List price: $21.95
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Average review score: 

Gives different perspective
Helpful Votes: 0 out of 0 total.
Review Date: 2006-02-25
Review Date: 2006-02-25
I found this a book insightful although very simplistic in writing style. It was helpful in giving other counselors a different way of looking at difficulties they have in some therapy sessions. Especially those clients that are stuck in one perspective and can not move off the safety square.
A BOOK WITH A SPECIAL MESSAGE
Helpful Votes: 10 out of 10 total.
Review Date: 2003-01-23
Review Date: 2003-01-23
Written with sincere compassion, and a warm, direct tone, Thom Rutledge gives us permission to be human, and helps the reader see that having fears, or tendencies to avoid those situations which create fear, is not a basis for shame. Embracing Fear teaches the reader to transform maladaptive responses, into winning situations, and the importance of finding the gift, lesson or opportunity in challenges we face. With his honest style, he helps us find the reason and rational messages we can listen to within our being when facing difficult or frightening situations. This is a man who knows of what he writes. His knowledge, personal experience, and ability to convey that he truly cares makes him a uniquley therapeutic and helpful writer. The reader is left feeling nurtured all along the way, and yet skillfully challenged as well. Wendy Oliver-Pyatt, MD author: Fed Up! The Breakthrough Ten Step No-Diet Fitness Plan.
Conquer your fears in this safe environment....
Helpful Votes: 11 out of 13 total.
Review Date: 2002-11-19
Review Date: 2002-11-19
I like this book because of Thom's simple, down-to-earth language and his sharing from his own personal experiences. He helps us realize how pervasively and unconsciously fear operates in our lives. His viewing fear as normal, rather than the result of personal weaknesses, enables us to see ourselves as struggling, growing and traveling together with him and others, not set apart and different. He has a safe, inviting approach to dealing with the Bullies, as he calls our fears. I believe, without exception, those who want to live their lives to the fullest will benefit from Thom's perspective and the steps to being in charge of fear. He holds our hand and convincingly shows us page by page.
Not an ordinary self-help book
Helpful Votes: 16 out of 16 total.
Review Date: 2005-04-09
Review Date: 2005-04-09
*****
This book is a great read all about fear. Specifically, it is about embracing fear---facing fear---rather than running from it, stuffing it, etc. Unlike most self-help books, the author does not presume to be an authority with easy answers; instead, he is a fellow human being who struggles with his own fear and that of his clients. He shares very practical techniques to approach your fears so that you can still have the life you want, regardless of your fears.
Fear underlies most if all negative emotions. I found this book to be very helpful. The author asks many helpful questions such as "What would I do today if I were brave?"...leading me to see where my fears stopped me.
Another technique he uses is splitting our self-talk into the negative voices of unhealthy unnecessary fear (which he calls The Bully) and the positive voices of what we know with our heads and hearts (which he calls The Ally). This has been really helpful to me, too. He makes the point that we will never rid ourselves of fear, but we will be less and less bothered by it as we learn how to face it.
This book differs from an ordinary self-help book in that it is amazingly useful, plus the author is practical, transparent, realistic, and humble. I loved reading it, highlighted it all over the place, and will read it again.
It is an excellent value and worth hours of therapy. I would even suggest it in lieu of therapy! I immediately bought two copies to send to two of my closest friends.
*****
This book is a great read all about fear. Specifically, it is about embracing fear---facing fear---rather than running from it, stuffing it, etc. Unlike most self-help books, the author does not presume to be an authority with easy answers; instead, he is a fellow human being who struggles with his own fear and that of his clients. He shares very practical techniques to approach your fears so that you can still have the life you want, regardless of your fears.
Fear underlies most if all negative emotions. I found this book to be very helpful. The author asks many helpful questions such as "What would I do today if I were brave?"...leading me to see where my fears stopped me.
Another technique he uses is splitting our self-talk into the negative voices of unhealthy unnecessary fear (which he calls The Bully) and the positive voices of what we know with our heads and hearts (which he calls The Ally). This has been really helpful to me, too. He makes the point that we will never rid ourselves of fear, but we will be less and less bothered by it as we learn how to face it.
This book differs from an ordinary self-help book in that it is amazingly useful, plus the author is practical, transparent, realistic, and humble. I loved reading it, highlighted it all over the place, and will read it again.
It is an excellent value and worth hours of therapy. I would even suggest it in lieu of therapy! I immediately bought two copies to send to two of my closest friends.
*****
Excellent Insights!
Helpful Votes: 5 out of 6 total.
Review Date: 2003-05-17
Review Date: 2003-05-17
This book will challenge you to look fear in the face and walk right though it! On the other side of fear is Love. If you want more love in your life. . . read this book!

From First Kicks to First Steps
Published in Paperback by McGraw-Hill (2004-08-11)
List price: $16.95
New price: $6.49
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Average review score: 

Not at all first rate - rather ordinary
Helpful Votes: 2 out of 20 total.
Review Date: 2006-11-03
Review Date: 2006-11-03
All I can say is that I am disappointed with this book.
The best book on pregnancy and the first year of your baby! Look no furthur.
Helpful Votes: 22 out of 23 total.
Review Date: 2006-09-12
Review Date: 2006-09-12
We're expecting our third child and I picked up this book because I liked the title. I figured almost two years worth of information in one book would be nice since we already kind of know about preganacy and the baby's first year. I wouldn't have to read too much with my busy schedule and maybe get one or two good tips I didn't get before. Was I wrong!
This book is not thin, total 317 pages. And yet, it reads so easy and fast (even considering my first language is not English). As I was reading this book, I was amazed how much information this book is packed with! This book covers not only the generic facts on how your baby grows, but also suggests what you can do as parent(s). It also has many wonderful photos.
Dr. Greene covers physical stuff such as nutrition, but also covers how you act and think may affect your baby. He also covers in detail how the baby develops - very informative and I had to read several passages to my husband. His respect and love for the life also can be felt throughout the book which also increased my own respect, awe, wonder, and love for our third baby.
I love to read and I've skimmed through many books on pregnancy, but this one is the best one and I am reading this thoroughly. This is like an all the best books on pregnancy and first year combined in one!
This book is not thin, total 317 pages. And yet, it reads so easy and fast (even considering my first language is not English). As I was reading this book, I was amazed how much information this book is packed with! This book covers not only the generic facts on how your baby grows, but also suggests what you can do as parent(s). It also has many wonderful photos.
Dr. Greene covers physical stuff such as nutrition, but also covers how you act and think may affect your baby. He also covers in detail how the baby develops - very informative and I had to read several passages to my husband. His respect and love for the life also can be felt throughout the book which also increased my own respect, awe, wonder, and love for our third baby.
I love to read and I've skimmed through many books on pregnancy, but this one is the best one and I am reading this thoroughly. This is like an all the best books on pregnancy and first year combined in one!
I love Dr. Greene!
Helpful Votes: 3 out of 3 total.
Review Date: 2008-01-07
Review Date: 2008-01-07
Although I read this book late in my pregnancy, I would recommend it to any expecting parents! I thought that his insight was more direct (and aligned to my own personal philosophies) than most expectant 'mom' books. Dr. Greene's other book, Raising Baby Green (my personal favorite), encouraged me to pick up this one, and I feel as though many moms and dads have a lot to learn from his experience as both father and pediatrician. Every question from should I eat organic to which diapers to use are covered- don't miss out on this book (it would also make a great shower or congratulations gift!)
Much needed comfort and advice
Helpful Votes: 4 out of 5 total.
Review Date: 2007-02-10
Review Date: 2007-02-10
My wife and I recently were blessed with the birth of our first child. Being new parents we often have felt overwhelmed and extremely inexperienced. Dr. Greene's book has proven informative and comforting in those moments when we needed a little helpful advice. "From First Kicks to First Steps" is easy and fun to read, and is a great resource for anyone with a little one at home or on the way.
Where Was This Book when We Were Expecting???
Helpful Votes: 7 out of 9 total.
Review Date: 2006-02-26
Review Date: 2006-02-26
Dr. Greene has put together a remarkable guideline that takes expecting couple from pregnancy through toddlerhood. Much like his award-winning children's health website, DrGreene.com, he does this in an engaging style with well-researched information.
Expectant mothers (and fathers) should look no further. This book is destined to be the "must-have" book for parents-to-be.
Daniel Z. Sands, MD, MPH
Assistant Clinical Professor, Harvard Medical School
Expectant mothers (and fathers) should look no further. This book is destined to be the "must-have" book for parents-to-be.
Daniel Z. Sands, MD, MPH
Assistant Clinical Professor, Harvard Medical School

Gentle's Holler
Published in Hardcover by (2005-03-03)
List price: $16.99
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Average review score: 

A Wonderful Book about Love, Hardship, and Hope
Helpful Votes: 0 out of 0 total.
Review Date: 2008-07-01
Review Date: 2008-07-01
Narrated in first-person by 12-year-old Livy Two Weems, Gentle's Holler tells the story of the Weems family living in the Maggie Valley area of the Smoky Mountains in the 1960s. With money hard to come by and 11 mouths to feed, the Weems don't have much. Daddy is a musician and has been trying to sell a banjo hit for years, and with nine children, Mamma is worn out. And what's more, there's something terribly wrong with three-year-old Gentle's vision. Livy Two comes up with a plan to train their dachshund Uncle Hazard to be a seeing eye dog and to teach Gentle how to read braille. But when tragedy strikes, the family struggles to survive and stay together.
From the very beginning of the book, you can hear Livy Two's voice and know instantly that she's spunky, smart, kind, and a bit loquacious. This voice carries through the book, and there were moments throughout when I laughed out loud, as I did here:
"I may come from a big family, but I already know I don't want children. I want my own house all to myself in the holler, and I swear I won't fill it with nothing but banjo music and vases of mountain laurel and plenty of food. My nieces and nephews will be allowed to visit on Saturday from one to two. I want a homemade rocking chair and a granny quilt on the bed and a rug from Persia on the floor. I wouldn't mind a fancy refrigerator or, even better, a record player like other regular folks have, and I would play me all kinds of music from Patsy Cline to Mozart." (pp. 54-55)
I found myself liking Livy Two and caring about what happened to this family, and Kerry Madden never lets the readers forget the poverty that surrounds the family. They're hungry. Livy Two often feels guilty and ashamed for sneaking an extra bite of cornbread, and her older brother Emmett, is angry at their father for letting them starve. They are unable to take Gentle to the doctor to get her eyes examined. When Daddy brings the dog, Uncle Hazard, home, Mama is furious because they now have another mouth to feed.
But despite this, it's evident that the family loves each other, and I was impressed with the way Kerry Madden was able to depict the love and tenderness that existed among this family. On one occasion, the tapping of a woodpecker inspires Daddy to pick up his banjo and start playing. Soon all of the children are singing and dancing, and Livy Two proclaims, "Sometimes our house is filled with so much love and happiness that a body can't hardly stand it." (p. 59)
On another occasion, Livy Two, overhears her sister Louise, trying to teach Gentle the colors through her senses,
"Pretty soon, I hear Louise carrying Gentle through the edge of the woods, telling her all about color. 'Now Gentle, eat this blueberry and you'll understand the color blue. Azure, sapphire, navy, and indigo. That's other names for blue.'" (88)
Gentle's Holler is a book about love, hardship, and hope. Livy Two teaches us to dream big and to never give up when faced with bad news. But she also teaches us to enjoy life regardless of how much or how little you have.
From the very beginning of the book, you can hear Livy Two's voice and know instantly that she's spunky, smart, kind, and a bit loquacious. This voice carries through the book, and there were moments throughout when I laughed out loud, as I did here:
"I may come from a big family, but I already know I don't want children. I want my own house all to myself in the holler, and I swear I won't fill it with nothing but banjo music and vases of mountain laurel and plenty of food. My nieces and nephews will be allowed to visit on Saturday from one to two. I want a homemade rocking chair and a granny quilt on the bed and a rug from Persia on the floor. I wouldn't mind a fancy refrigerator or, even better, a record player like other regular folks have, and I would play me all kinds of music from Patsy Cline to Mozart." (pp. 54-55)
I found myself liking Livy Two and caring about what happened to this family, and Kerry Madden never lets the readers forget the poverty that surrounds the family. They're hungry. Livy Two often feels guilty and ashamed for sneaking an extra bite of cornbread, and her older brother Emmett, is angry at their father for letting them starve. They are unable to take Gentle to the doctor to get her eyes examined. When Daddy brings the dog, Uncle Hazard, home, Mama is furious because they now have another mouth to feed.
But despite this, it's evident that the family loves each other, and I was impressed with the way Kerry Madden was able to depict the love and tenderness that existed among this family. On one occasion, the tapping of a woodpecker inspires Daddy to pick up his banjo and start playing. Soon all of the children are singing and dancing, and Livy Two proclaims, "Sometimes our house is filled with so much love and happiness that a body can't hardly stand it." (p. 59)
On another occasion, Livy Two, overhears her sister Louise, trying to teach Gentle the colors through her senses,
"Pretty soon, I hear Louise carrying Gentle through the edge of the woods, telling her all about color. 'Now Gentle, eat this blueberry and you'll understand the color blue. Azure, sapphire, navy, and indigo. That's other names for blue.'" (88)
Gentle's Holler is a book about love, hardship, and hope. Livy Two teaches us to dream big and to never give up when faced with bad news. But she also teaches us to enjoy life regardless of how much or how little you have.
Introduction to the Weems family is a great read!
Helpful Votes: 1 out of 1 total.
Review Date: 2008-04-27
Review Date: 2008-04-27
Gentle's Holler was my introduction to the Weems family. Totally enjoyable! Although the book is listed under youth fiction, I (well past youth) found the book absolutely delightful.
Quiet Power of 'Gentle's Holler'
Helpful Votes: 1 out of 1 total.
Review Date: 2007-12-01
Review Date: 2007-12-01
Kerry Madden tells a beautiful story in "Gentle's Holler." While on the surface it seems a simple story, it unfolds with a quiet power that resonates with the reader. Although it is written for young people, it held this older reader from first word to the last. And I will pass it on to my young friends and family, recommended highly.
A great family story
Helpful Votes: 1 out of 1 total.
Review Date: 2007-06-10
Review Date: 2007-06-10
In Gentle's Holler Kerry Madden deftly portrays the difficult lives of this family of ten without losing the musical voice of the 12-year-old heroine. As readers see "Livy Two" grow through her new perceptions of her parents, her older siblings and her blind baby sister, they can experience many wondrous complexities of family dynamics. It's a great read in the tradition of Betsy Byars. Readers who enjoy Gentle's Holler might also enjoy Danger, Long Division, in which a modern Maryland latch-key kid discovers that she has what it takes to help her baby brother who has special needs.
A Sweet and Gentle Story
Helpful Votes: 3 out of 3 total.
Review Date: 2007-03-28
Review Date: 2007-03-28
In GENTLE'S HOLLER, Kerry Madden introduced young readers to Olivia (better known as Livy Two) Weems, a twelve-year-old with a passion for books and music. Livy has eight siblings of various ages and tempermants, a sweet mama, and a starry-eyed daddy. Money's tight - Daddy's music fills the heart and ears more than it fills the pocketbook - but the Weems make do, and their household is always bursting with family, love, and music. Livy Two also sings and plays music, often writing songs about the struggles her family has faced and the hardships they've overcome. The story is set in 1960s North Carolina, a beautiful backdrop for this artistic and energetic family.
As the tale progresses, Livy Two watches carefully over Gentle, the next-to-youngest one in the family, who has always had difficulty with her eyes. Meanwhile, the eldest son, Emmett, looks beyond the holler and fixes his eyes on Ghost Town in the Sky, a new place on the top of a mountain where he might be able to get a job. Livy Two's trips to the lending library truck connect her with another kind soul, Miss Attickson, who encourages Livy's voracious appetite for novels and poetry.
GENTLE'S HOLLER is the first in The Maggie Valley Trilogy. The second book, LOUISIANA'S SONG, is just as precious as the first book. I can't wait to read JESSIE'S MOUNTAIN, the final book in the trilogy. This series will be loved by kids and families who enjoyed the All-of-a-Kind Family books by Sidney Taylor, The Penderwicks by Jeanne Birdsall, and Cheaper by the Dozen and Belles on Their Toes by Frank B. Gilbreth and Ernestine Gilbreth Carey.
As the tale progresses, Livy Two watches carefully over Gentle, the next-to-youngest one in the family, who has always had difficulty with her eyes. Meanwhile, the eldest son, Emmett, looks beyond the holler and fixes his eyes on Ghost Town in the Sky, a new place on the top of a mountain where he might be able to get a job. Livy Two's trips to the lending library truck connect her with another kind soul, Miss Attickson, who encourages Livy's voracious appetite for novels and poetry.
GENTLE'S HOLLER is the first in The Maggie Valley Trilogy. The second book, LOUISIANA'S SONG, is just as precious as the first book. I can't wait to read JESSIE'S MOUNTAIN, the final book in the trilogy. This series will be loved by kids and families who enjoyed the All-of-a-Kind Family books by Sidney Taylor, The Penderwicks by Jeanne Birdsall, and Cheaper by the Dozen and Belles on Their Toes by Frank B. Gilbreth and Ernestine Gilbreth Carey.

The Guilty Innocent: Knights of the Darkness Book Two (Knights of the Darkness Chronicles)
Published in Paperback by AuthorHouse (2005-08-18)
List price: $14.95
New price: $8.86
Used price: $8.54
Used price: $8.54
Average review score: 

I LOVED IT!!! Bring on the Royal Flush!
Helpful Votes: 10 out of 13 total.
Review Date: 2006-07-29
Review Date: 2006-07-29
This book has me laughing from cover to cover, but I loved the ACTION! I mean there was bullets flying, people dying, it was awesome. And the ending of this book just blew me away, one of the sexiest scenes I've EVER read in this type of novel and done so well.
I like that D.N. isn't vulgar about her sex scenes and each character, you can't help but respect because they're written so well. I love D.N.'s supernaturals, unlike many other books, I like that they have a loyalty to each other that really stands out and they don't angst, whine and cry about everything. They do what's gotta be done and kick butt in the process. D.N.'s a great writer and I can see that she's improving her writing style in this book because it really shows. I can't wait for the third book, it can't get to me fast enough. The forum/website said it's coming in August and that's almost too far away.
I like that D.N. isn't vulgar about her sex scenes and each character, you can't help but respect because they're written so well. I love D.N.'s supernaturals, unlike many other books, I like that they have a loyalty to each other that really stands out and they don't angst, whine and cry about everything. They do what's gotta be done and kick butt in the process. D.N.'s a great writer and I can see that she's improving her writing style in this book because it really shows. I can't wait for the third book, it can't get to me fast enough. The forum/website said it's coming in August and that's almost too far away.
For the true vampire at heart
Helpful Votes: 14 out of 17 total.
Review Date: 2006-07-19
Review Date: 2006-07-19
Bored to death after reading many other so called vampire books out there, I researched on-line for the next vampire thrill. I stumbled upon a website and Desires Unleashed (1st book) was mentioned on the blogs. Caught my curiosity and purchased it. Fell in love with it regardless of the misspellings. It's lustful (not in a girly/Fabio way) it's sinful, and it's so erotic. All in a vampire-lish way. It's animalistic, it's raw. I even purchased another one for a friend. DN Simmons has a cult following now these days and I am one of them. Bought the second book, The Guilty Innocent, and I am presently reading it for the second time. I am totally hooked. I want more. These books are addictive. Can't wait for Royal Flush!!!!
Can't wait for the next one!
Helpful Votes: 18 out of 22 total.
Review Date: 2006-06-06
Review Date: 2006-06-06
Great book! Better editing than the first book, so that was good. Awesome storyline! Sergio, who is my favorite character kicked butt in this book! D.N.'s writing style is improving with each book it seems and I'm really enjoying this series.
I'd totally recommend reading the KOTDC.
I'd totally recommend reading the KOTDC.
Fun and sexy ride.
Helpful Votes: 8 out of 9 total.
Review Date: 2006-11-18
Review Date: 2006-11-18
I have 3 of the books in this series, and I found it refreshing compared to some have I've read.
The books are fast paced, the plot(yes there is a plot) moves smoothly.
The descriptions of Chicago takes me back to when I lived there, I can see the places she describes, and only an exceptional writer can do that.
Yes, the supernaturals are beautiful, what supernaturals in what series are not. There are sex scenes in the books, what supernatural novel being written now does not, yet the sex is believable, well writtten and there is no "F**ck me while I'm tight" being screamed at every encounter, and sex is not the energizer bunny powering up everyone within a 10 mile radius. Yes some of the characters are homosexual, and no I do not remember reading that all of them were submissive, they are well written characters. Characters who some can relate to, characters that although are supernatural have problems of life and love and resolve them in the way you woule expect supernaturals to do so.
Yes, there are typos, but once informed of this, Ms. Simmons has promised to correct them in the next release of these books. I applaud and commend her, she is a self-published author, she did not have proofreaders, editors, a husband or reading group to help her along.
I'd gladly pay 25 bucks for her next novel.
The books are fast paced, the plot(yes there is a plot) moves smoothly.
The descriptions of Chicago takes me back to when I lived there, I can see the places she describes, and only an exceptional writer can do that.
Yes, the supernaturals are beautiful, what supernaturals in what series are not. There are sex scenes in the books, what supernatural novel being written now does not, yet the sex is believable, well writtten and there is no "F**ck me while I'm tight" being screamed at every encounter, and sex is not the energizer bunny powering up everyone within a 10 mile radius. Yes some of the characters are homosexual, and no I do not remember reading that all of them were submissive, they are well written characters. Characters who some can relate to, characters that although are supernatural have problems of life and love and resolve them in the way you woule expect supernaturals to do so.
Yes, there are typos, but once informed of this, Ms. Simmons has promised to correct them in the next release of these books. I applaud and commend her, she is a self-published author, she did not have proofreaders, editors, a husband or reading group to help her along.
I'd gladly pay 25 bucks for her next novel.
Self published author lays a smack down
Helpful Votes: 8 out of 10 total.
Review Date: 2006-11-17
Review Date: 2006-11-17
There have been authors and then there have been authors.
As a love leter to D.N.Simmons, first let me say, "Do Your Thang!"
The Guilty Innocent, gave me the best ride of my book reading life, I love that although Natasha is the one telling the story, that Natasha is not the story.
I love that the vampires aren't campy or have fallen head over heels for her simply because Natasha is the one telling the story.
I love that there are other strong women in this series, who aren't a threat to her and if they are she says it and so be it.
I could pull a recap of what another reveiewer said and tell you the story, but I have a better idea for you, buy the book, it's worth the price.
As a love leter to D.N.Simmons, first let me say, "Do Your Thang!"
The Guilty Innocent, gave me the best ride of my book reading life, I love that although Natasha is the one telling the story, that Natasha is not the story.
I love that the vampires aren't campy or have fallen head over heels for her simply because Natasha is the one telling the story.
I love that there are other strong women in this series, who aren't a threat to her and if they are she says it and so be it.
I could pull a recap of what another reveiewer said and tell you the story, but I have a better idea for you, buy the book, it's worth the price.

Hell and High Water: Global Warming--the Solution and the Politics--and What We Should Do
Published in Hardcover by William Morrow (2007-01-01)
List price: $24.95
New price: $5.99
Used price: $4.00
Used price: $4.00
Average review score: 

Journalists should read this!
Helpful Votes: 0 out of 0 total.
Review Date: 2008-03-05
Review Date: 2008-03-05
I hope journalists discover this book and take a harder/firmer stance on global warming.
Very well done, Mr. Romm!!!
Very well done, Mr. Romm!!!
Best Available Book on Climate Change
Helpful Votes: 0 out of 0 total.
Review Date: 2008-02-29
Review Date: 2008-02-29
There are literally dozens of excellent books on global warming and climate change, but this one is the best. It's part science, part social commentary, and all of it is fascinating. The author does a terrific job of giving us the basic facts, then moves us right into the troubled waters of policy, societal inertia, and consequences if we do not do something. Especially eye-opening was chapter 6 "The Technology Trap and the American Way of Life", in which he presents a compelling case that technology could theoretically be used to solve global warming problems, but the reality is that it is used as a promised "Deus ex machina" technological fix to get us out of trouble - the problem of course, is that this solution is always in the future (such as the availability of hydrogen power always being 10-15 years away, beginning in the early 1970s).
One of his insightful sections titled "Voluntary Warming" indicates the direct, no-nonsense approach taken in this book: "It is hard to imagine that people will use low-carbon technologies on the vast scale needed until they see a financial return for cutting carbon, and that will not happen until spewing out carbon has a significant financial cost. But for carbon to have a cost, the government must either tax carbon dioxide emissions or create a market that establishes a price for emitting carbon dioxide".
If you read just one book on the subject, I recommend this one, for reasons that are numerous, and have been well-elaborated in the other 5-star reviews.
One of his insightful sections titled "Voluntary Warming" indicates the direct, no-nonsense approach taken in this book: "It is hard to imagine that people will use low-carbon technologies on the vast scale needed until they see a financial return for cutting carbon, and that will not happen until spewing out carbon has a significant financial cost. But for carbon to have a cost, the government must either tax carbon dioxide emissions or create a market that establishes a price for emitting carbon dioxide".
If you read just one book on the subject, I recommend this one, for reasons that are numerous, and have been well-elaborated in the other 5-star reviews.
Wake Up Call
Helpful Votes: 1 out of 6 total.
Review Date: 2007-06-10
Review Date: 2007-06-10
It's time to wake up to what's going on with our world and what we're doing to it. As a long time participant in the petroleum and related industries worldwide it has long been evident that we are exhausting the world's resources at an unsustainable rate detrimental to life as we know it and to a livable environment. Damon A. Peteron
Great informative book
Helpful Votes: 2 out of 5 total.
Review Date: 2007-05-19
Review Date: 2007-05-19
If you want the facts about global warming and what we need to do about it straight from the experts' mouths, this is the book for you. It covers everything about global warming from the media's bias to the various policies we need to implement to avoid catastrophic climate change, to the consequences if we fail to avoid it. Absolutely fantastic book.
Alarming--because it's factual
Helpful Votes: 4 out of 5 total.
Review Date: 2007-08-17
Review Date: 2007-08-17
As an environmental policy grad student, I thought I had a pretty good idea of what we're in for with climate change. But after reading this book I've realized that, oh no, it's worse than I thought. The book starts out by describing the nasty potential futures facing us if we fail to take sufficient action, and soon. This bit comes across as somewhat sensational, but Romm quickly moves in a very well done review of the scientific literature backing up the scary part. The account of the unified effort to deny the validity of climate change and delay action is also well executed.
Highly recommended for anyone who needs a little motivation to start caring about climate change!
Highly recommended for anyone who needs a little motivation to start caring about climate change!
Books-Under-Review-->Arts-->Literature-->Authors-->N-->48
Related Subjects: Nabhan, Gary Paul Nash, Ogden Nashe, Thomas Nelson, Marilyn Neruda, Pablo Nye, Naomi Shihab Nabokov, Vladimir Nin, Anais Neri, Kris Nicholson, Peter Nesbit, Edith Ngugi wa Thiong'o Norris, Robert W. Nicholson, Geoff Novalis Novo, Salvador Nooteboom, Cees Newman, Amy Niland, D'Arcy Narayan, R. K. Nassise, Joseph Nichol, B. P. Nasaw, Jonathan Nottingham, Theodore J.
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Related Subjects: Nabhan, Gary Paul Nash, Ogden Nashe, Thomas Nelson, Marilyn Neruda, Pablo Nye, Naomi Shihab Nabokov, Vladimir Nin, Anais Neri, Kris Nicholson, Peter Nesbit, Edith Ngugi wa Thiong'o Norris, Robert W. Nicholson, Geoff Novalis Novo, Salvador Nooteboom, Cees Newman, Amy Niland, D'Arcy Narayan, R. K. Nassise, Joseph Nichol, B. P. Nasaw, Jonathan Nottingham, Theodore J.
More Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250